238422-39-4

Usage

Uses

Used in Pharmaceutical Research and Development:
(6-BROMO-8-METHOXYIMIDAZO[1,2-A]PYRAZIN-3-YL)METHANOL is used as a compound in pharmaceutical research and development for its potential medicinal properties. The unique molecular structure, including the bromine atom and methoxy group, may contribute to its effectiveness in targeting specific biological pathways or receptors, thus offering therapeutic benefits.
Used in Drug Formulation:
Due to its methanol group, (6-BROMO-8-METHOXYIMIDAZO[1,2-A]PYRAZIN-3-YL)METHANOL is used as a component in drug formulation to improve solubility and stability. This characteristic can be crucial for the development of effective medications, as it may enhance the compound's bioavailability and overall performance in treating various medical conditions.
Further research is necessary to fully understand the potential uses and implications of (6-bromo-8-methoxyimidazo[1,2-a]pyrazin-3-yl)methanol in the field of medicinal chemistry, as well as to explore its possible applications in other industries.

Upstream product

• 50-00-0 formaldehyd 
• 63744-25-2 6-bromo-8-methoxyimidazo[1,2-a]pyrazine 

Downstream Products

• 187344-68-9 6-bromo-3-(hydroxymethyl)-8-(methylamino)imidazo<1,2-a>pyrazine 

Relevant academic research and scientific papers

Aza-indolizine with bridgehead nitrogen. Metalation, halogen-metal exchange and directed ortho-lithiation in the imidazo[1,2-a]pyrazine series

The n-BuLi and lithium 2,2,6,6-tetramethylpiperidine (LTMP) metalation of intidazo[1,2-a]pyrazine heterocycles and subsequent quenching with electrophiles is described. Bromine atoms exhibit different behaviours towards lithiation depending on their positions (3 or 6) on the imidazo[1,2- a]pyrazine heterocycle. Halogen-metal exchange occurs readily with the bromine on position 3. On the contrary, bromine on position 6 only leads to C-5 substituted derivatives further to an ortho-directing effect.

Synthesis and Antibronchospastic Activity of 8-Alkoxy- and 8-(Alkylamino)imidazopyrazines

Theophylline still occupies a dominant place in asthma therapy.Unfortunatly its adverse central nervous system (CNS) stimulant effects can dramatically limit its use, and adjustments in the dosage are often needed.We have synthesized a new series of imidazopyrazine derivatives which are much more potent bronchodilators than theophylline in vivo and do not exhibit the CNS stimulatory profile.In vitro studies on isolated rat uterus and guinea pig trachea confirm the high potentialities of these derivatives. 6-Bromo-8-(methylamino)imidazopyrazine-3-carbonitrile (23) is identified as the most potent compound of the series.As i n the case of theophylline, phosphodiesterase inhibition appears unlikely to be the unique mechanism of the action of this series of heterocycles.