23851-59-4

Upstream product

• 21776-68-1 N-[4-(5-amino-benzo[1,2,3]triazol-2-yl)-phenyl]-acetamide 
• 108-45-2 m-phenylenediamine 
• 64264-33-1 2-phenyl-5-nitrobenzotriazole 
• 18371-12-5 N-[4-(2,4-Diamino-phenylazo)-phenyl]-acetamide 
• 541-69-5 m-phenylenediamine dihydrochloride 
• 19089-87-3 4-acetamido-benzenediazonium cation 
• 108777-67-9 5-nitro-2-(4-nitro-phenyl)-2H-benzotriazole 

Relevant academic research and scientific papers

Basic azo dyestuffs of the 3-cyano-2,4,6-triamino pyridine series

The new basic azo dyestuffs of the formula STR1 wherein the symbols have the meaning given in the description, are suitable for dyeing synthetic and naturally occurring substrates which can be dyed with basic dyestuffs.

APPLICATION OF FLUORESCENT TRIAZOLES TO ANALYTICAL CHEMISTRY. III. FLUORESCENCE CHARACTERISTICS OF 2-PHENYLBENZOTRIAZOLYL-5-AMINE DERIVATIVES AS FLUORESCENT PROBES

2-Phenylbenzotriazole derivatives with a COCH3 or NH2 group on the 2-phenyl ring were synthesized and found to be applicable as fluorescent hydrophobic probes.The fluorescence intensities of these compounds, which were intense in non-polar solvents, were dramatically quenched in polar solvents.In particular, 2-(4-acetylphenyl)-2H-benzotriazolyl-5-amine (7) showed a much higher ratio of the fluorescence intensity in the organic solvent to that in water (Fo/Fw) than 8-anilino-1-naphthalenesulfonate (ANS): The Fo/Fw values of 7 were 470 for dioxane and 440 for acetone, while those of ANS were 100 for dioxane and 90 for acetone.We modified compound 7 to obtain water-soluble probes for use in drug-protein binding studies and examined the interaction of these probes with human serum albumin (HSA).All the compounds, which were practically non-fluorescent in the buffer solution, bound to HSA and fluoresced.Keywords: 2-phenylbenzotriazolyl-5-amine; fluorescence characteristies; solvent effect; fluorescent probe; protein binding