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23851-84-5

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23851-84-5 Usage

General Description

4-HYDROXY-8-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLIC ETHYL ESTER is a chemical compound that belongs to the group of quinoline carboxylic acid esters. It is an ethyl ester derivative of quinoline, which contains a hydroxy group at the 4-position and a trifluoromethyl group at the 8-position. 4-HYDROXY-8-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLIC ETHYL ESTER is commonly used in organic synthesis and medicinal chemistry as a building block or intermediate for the preparation of various pharmaceuticals and agrochemicals. It has also been studied for its potential biological activities, including anti-inflammatory and anticancer properties.

Check Digit Verification of cas no

The CAS Registry Mumber 23851-84-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,3,8,5 and 1 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 23851-84:
(7*2)+(6*3)+(5*8)+(4*5)+(3*1)+(2*8)+(1*4)=115
115 % 10 = 5
So 23851-84-5 is a valid CAS Registry Number.
InChI:InChI=1/C9H12F3N3/c1-8(2,3)5-4-6(9(10,11)12)15-7(13)14-5/h4H,1-3H3,(H2,13,14,15)

23851-84-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name ethyl 4-oxo-8-(trifluoromethyl)-1H-quinoline-3-carboxylate

1.2 Other means of identification

Product number -
Other names Ethyl 4-Hydroxy-8-(trifluoromethyl)-3-quinolinecarboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:23851-84-5 SDS

23851-84-5Downstream Products

23851-84-5Relevant articles and documents

Click chemistry approach: Regioselective one-pot synthesis of some new 8-trifluoromethylquinoline based 1,2,3-triazoles as potent antimicrobial agents

Garudachari,Isloor, Arun M.,Satyanarayana,Fun, Hoong-Kun,Hegde, Gurumurthy

, p. 324 - 332 (2014/02/14)

Three series of 8-trifluoromethylquinoline based 1,2,3-triazoles derivatives (5a-c, 6a-d and 7a-c) were synthesized by multi-step reactions by click chemistry approach. Synthesized compounds were characterized by spectral studies and X-ray analysis. The final compounds were screened for their in-vitro antimicrobial activity by well plate method (zone of inhibition). Compounds 5c, 6b, 8b, 11 and 12 were found to be active against tested microbial strains. The results are summarized in Tables 5 and 6.

Design and regioselective synthesis of trifluoromethylquinolone derivatives as potent antimicrobial agents

Garudachari,Isloor, Arun M.,Satyanarayana,Fun, Hoong-Kun,Pavithra,Kulal, Ananda

, p. 422 - 432 (2013/10/01)

Three series of new trifluoromethyl substituted quinolone derivatives were synthesized (4a-f, 6a-f and 8a-f) from corresponding substituted anilines by multi-step reactions. The regioselective alkylation with different alkyl halides were carried out by approaching two different routes to get the final products in good yield. Newly synthesized compounds were characterized by spectral study and also by C, H, N analyses. Three dimensional structure of 2b and 4b were also confirmed by single crystal X-ray studies. The final compounds (4a-f, 6a-f and 8a-f) were screened for their in-vitro antibacterial and antifungal activity by well plate method (zone of inhibition). The results revealed that, compounds 4a, 6b, 6c and 8e showed significant antibacterial activity as compared to the standard drug Ciprofloxacin. The compound 8a was found to be a potent antifungal agent.

Design and synthesis of some new quinoline-3-carbohydrazone derivatives as potential antimycobacterial agents

Eswaran, Sumesh,Adhikari, Airody Vasudeva,Pal, Nishith K.,Chowdhury, Imran H.

supporting information; experimental part, p. 1040 - 1044 (2010/06/14)

A series of 26 new quinoline derivatives carrying active pharmacophores has been synthesized and evaluated for their in vitro antituberculosis activity against Mycobacterium tuberculosis H37Rv (MTB), Mycobacterium smegmatis (MC2), and Mycobacterium fortuitum following the broth micro dilution assay method. Compounds 13e, 13i, 13k, 14a, 14c, 14i, and 14k exhibited significant minimum inhibition concentrations, when compared with first line drugs isoniazid (INH) and rifampicin (RIF) and could be ideally suited for further modifications to obtain more efficacious compounds in the fight against multi-drug resistant tuberculosis.

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