1346226-41-2

Basic information

• Product Name: 4-hydroxy-8-trifluoromethyl-quinoline-3-carboxylic acid [4-(1,1,2,2-tetrafluoro-ethoxy)-benzylidene]-hydrazide
• Synonyms: 4-hydroxy-8-trifluoromethyl-quinoline-3-carboxylic acid [4-(1,1,2,2-tetrafluoro-ethoxy)-benzylidene]-hydrazide
• CAS NO: 1346226-41-2
• Molecular Weight: 475.322
• Mol File: 1346226-41-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-hydroxy-8-trifluoromethyl-quinoline-3-carboxylic acid [4-(1,1,2,2-tetrafluoro-ethoxy)-benzylidene]-hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-hydroxy-8-trifluoromethyl-quinoline-3-carboxylic acid [4-(1,1,2,2-tetrafluoro-ethoxy)-benzylidene]-hydrazide(1346226-41-2)
• EPA Substance Registry System: 4-hydroxy-8-trifluoromethyl-quinoline-3-carboxylic acid [4-(1,1,2,2-tetrafluoro-ethoxy)-benzylidene]-hydrazide(1346226-41-2)

Safety Data

• Hazardous Substances Data: 1346226-41-2(Hazardous Substances Data)

Upstream product

• 873942-91-7 4-hydroxy-8-(trifluoromethyl)quinoline-3-carbohydrazide 
• 35295-36-4 4-(1,1,2,2-tetrafluoro-ethoxy)-benzaldehyde 
• 23779-94-4 2-[(2-trifluoromethylphenylamino)methylene]malonic acid diethyl ester 
• 23851-84-5 4-hydroxy-8-trifluoromethyl-quinoline-3-carboxylic acid ethyl ester 
• 88-17-5 2-(trifluoromethyl)benzenamine 

Relevant articles and documents

Design, synthesis and docking studies of new quinoline-3-carbohydrazide derivatives as antitubercular agents

Three new series of 4-hydroxy-8-trifluoromethyl-quinoline derivatives were synthesized through multi step reactions. All the newly synthesized compounds were characterized by spectral and elemental analyses. The structure of 5j was evidenced by X-ray crystallographic study. The newly synthesized title compounds were evaluated for their antimicrobial activities including antimycobacterial activity. Amongst the tested compounds, 5b, 5e, 5h, 5j, 6c and 7c displayed promising antimicrobial activity. The mode of action of these active compounds was carried out by docking of receptor enoyl-ACP reductase with newly synthesized candidate ligands, 5b, 5e, 5h, 5j and 6c.