238748-33-9

Upstream product

• 100-51-6 benzyl alcohol 
• 226067-51-2 N-[(2R,3S)-2-bromo-3-hydroxy-4-methylpentanoyl]-(1S,5R,7R)-10,10-dimethyl-3-thioxo-2-aza-4-oxatricyclo[6.2.1.0^1,5]decane 
• 428512-42-9 benzyl (4R,5S)-5-isopropyl-1,3,2-dioxathiolane-4-carboxylate 2,2-dioxide 
• 226417-44-3 phenylmethyl (2R,3S)-2-bromo-3-hydroxy-4-methylpentanoate 

Downstream Products

• 428512-46-3 benzyl (2S,3R)-N^α-(benzyloxycarbonyl)-3-isopropylaziridine-2-carboxylate 
• 870528-57-7 (3S,4S,8S)-8-Isopropyl-2-[(S)-1-(4-methoxy-phenyl)-ethyl]-1,6-dioxo-3-(2-trimethylsilanyl-furan-3-yl)-7-oxa-2,5-diaza-spiro[3.4]octane-5-carboxylic acid tert-butyl ester 
• 870528-58-8 [(3S,4S)-3-((S)-1-Hydroxy-2-methyl-propyl)-1-[(S)-1-(4-methoxy-phenyl)-ethyl]-2-oxo-4-(2-trimethylsilanyl-furan-3-yl)-azetidin-3-yl]-carbamic acid tert-butyl ester 
• 870528-60-2 [(3S,4S)-3-((S)-1-Hydroxy-2-methyl-propyl)-1-[(S)-1-(4-methoxy-phenyl)-ethyl]-2-oxo-4-((R)-2-oxo-tetrahydro-furan-3-yl)-azetidin-3-yl]-carbamic acid tert-butyl ester 
• 870528-59-9 [(3S,4S)-3-((S)-1-Hydroxy-2-methyl-propyl)-1-[(S)-1-(4-methoxy-phenyl)-ethyl]-2-oxo-4-(2-oxo-2,5-dihydro-furan-3-yl)-azetidin-3-yl]-carbamic acid tert-butyl ester 
• 870528-61-3 (1S,4R,5S)-4-(2-Hydroxy-ethyl)-1-((S)-1-hydroxy-2-methyl-propyl)-6-[(S)-1-(4-methoxy-phenyl)-ethyl]-2,6-diaza-bicyclo[3.2.0]heptane-3,7-dione 
• 870528-62-4 (1S,4R,5S)-4-(2-Chloro-ethyl)-1-((S)-1-hydroxy-2-methyl-propyl)-6-[(S)-1-(4-methoxy-phenyl)-ethyl]-2,6-diaza-bicyclo[3.2.0]heptane-3,7-dione 
• 870528-55-5 (4S,5S) 5-isopropyl-2-oxo-oxazolidine-3,4-dicarboxylic acid 4-benzyl ester 3-tert-butyl ester 
• 870528-54-4 (4S,5S) 5-isopropyl-2-oxo-oxazolidine-4-carboxylic acid benzyl ester 
• 428512-45-2 benzyl (2S,3R)-3-isopropyl-aziridine-2-carboxylate 

Relevant academic research and scientific papers

A general asymmetric synthesis of syn- and anti-beta-substituted cysteine and serine derivatives.

A stereodivergent synthetic route has been developed to make the optically pure anti- and syn-beta-substituted cysteine and serine derivatives. In this approach, the key intermediates, > 94% enantiomerically pure cyclic sulfates 3 and aziridines 7, were prepared from alpha,beta-unsaturated esters 1, employing the Sharpless asymmetric dihydroxylation. The high regio- and stereoselective ring-opening reactions of cyclic sulfates and aziridines provided enantiomerically pure beta-substituted cysteine and serine derivatives.