870528-58-8

Upstream product

• 238748-33-9 phenylmethyl (2S,3S)-2-azido-3-hydroxy-4-methylpentanoate 
• 137044-67-8 2-(trimethylsilyl)-3-furaldehyde 
• 6298-96-0 (S)-1-(4-methoxyphenyl)ethylamine 
• 870528-55-5 (4S,5S) 5-isopropyl-2-oxo-oxazolidine-3,4-dicarboxylic acid 4-benzyl ester 3-tert-butyl ester 
• 870528-56-6 [(S)-1-(4-Methoxy-phenyl)-ethyl]-[1-(2-trimethylsilanyl-furan-3-yl)-meth-(E)-ylidene]-amine 
• 125414-69-9 (4S,5S) 5-isopropyl-2-oxo-oxazolidine-3,4-dicarboxylic acid 3-tert-butyl ester 
• 870528-54-4 (4S,5S) 5-isopropyl-2-oxo-oxazolidine-4-carboxylic acid benzyl ester 
• 870528-57-7 (3S,4S,8S)-8-Isopropyl-2-[(S)-1-(4-methoxy-phenyl)-ethyl]-1,6-dioxo-3-(2-trimethylsilanyl-furan-3-yl)-7-oxa-2,5-diaza-spiro[3.4]octane-5-carboxylic acid tert-butyl ester 

Downstream Products

• 870528-59-9 [(3S,4S)-3-((S)-1-Hydroxy-2-methyl-propyl)-1-[(S)-1-(4-methoxy-phenyl)-ethyl]-2-oxo-4-(2-oxo-2,5-dihydro-furan-3-yl)-azetidin-3-yl]-carbamic acid tert-butyl ester 
• 870528-62-4 (1S,4R,5S)-4-(2-Chloro-ethyl)-1-((S)-1-hydroxy-2-methyl-propyl)-6-[(S)-1-(4-methoxy-phenyl)-ethyl]-2,6-diaza-bicyclo[3.2.0]heptane-3,7-dione 
• 870528-61-3 (1S,4R,5S)-4-(2-Hydroxy-ethyl)-1-((S)-1-hydroxy-2-methyl-propyl)-6-[(S)-1-(4-methoxy-phenyl)-ethyl]-2,6-diaza-bicyclo[3.2.0]heptane-3,7-dione 
• 870528-60-2 [(3S,4S)-3-((S)-1-Hydroxy-2-methyl-propyl)-1-[(S)-1-(4-methoxy-phenyl)-ethyl]-2-oxo-4-((R)-2-oxo-tetrahydro-furan-3-yl)-azetidin-3-yl]-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Proteasome inhibiting beta-lactam compounds

Disclosed is a total synthesis of a biologically active β-Lactam—Compound 3, which is related to Salinosporamide A and Omuralide, both structurally and by its activity as a proteasome inhibitor. Also disclosed are proteasome inhibiting compounds having th

Proteasome inhibition by a totally synthetic β-lactam related to salinosporamide A and omuralide

A new and effective proteasome inhibitor, β-lactam 3, has been accessed enantioselectively by multistep synthesis from the readily prepared intermediates 7 and 8 which were joined by a [2 + 2]-cycloaddition reaction to form the spiro β-lactam 9 stereosele