23875-84-5

Upstream product

• 64-18-6 formic acid 
• 1073-69-4 N-4-chlorophenylhydrazine 
• 57-13-6 urea 
• 14580-27-9 1-(4-chloro-phenyl)-semicarbazide 
• 122-51-0 orthoformic acid triethyl ester 

Downstream Products

• 120590-04-7 <<1-(4-chlorophenyl)-1H-1,2,4-triazol-3-yl>oxy>acetic acid ethyl ester 
• 110607-65-3 1-(4-chlorophenyl)-3-(1-ethoxycarbonylethoxy)-1,2,4-1H-triazole 

Relevant academic research and scientific papers

Discovery of novel triazole-containing pyrazole ester derivatives as potential antibacterial agents

To develop new antibacterial agents, a series of novel triazole-containing pyrazole ester derivatives were designed and synthesized and their biological activities were evaluated as potential topoisomerase II inhibitors. Compound 4d exhibited the most potent antibacterial activity with Minimum inhibitory concentration (MIC) alues of 4 μg/mL, 2 μg/mL, 4 μg/mL, and 0.5 μg/mL against Staphylococcus aureus, Listeria monocytogenes, Escherichia coli, and Salmonella gallinarum, respectively. The in vivo enzyme inhibition assay 4d displayed the most potent topoisomerase II (IC50 = 13.5 μg/mL) and topoisomerase IV (IC50 = 24.2 μg/mL) inhibitory activity. Molecular docking was performed to position compound 4d into the topoisomerase II active site to determine the probable binding conformation. In summary, compound 4d may serve as potential topoisomerase II inhibitor.

Synthesis and antifungal activity evaluation of new 1,2,4-triazole derivatives bearing salicylidene hydrazide moiety

A series of new N'-(arylidene)-2-[(1-(4-nitrophenyl)-1H-1,2,4-triazol-3-yl)oxy]acetohydrazide derivatives (1- 16) were prepared and tested for theira ntifungal activity against six plant pathogens, three human pathogens and two nonpathogen microorganisms. The target compounds were obtained with a multi-step reaction starting from 4- substitutedarylhydrazine derivatives and the structures of final compounds have been elucidated with IR, NMR, Mass spectroscopy data and elemental analysis results. The antifungal activity of the compounds was determined against eleven different Fusarium, Trichoderma, Aspergillus and Penicilliumspeciesby using microdilution method. Most of the target compounds showed excellent antifungal activity against a variety of fungal pathogens.

Synthesis of Ethyl 2-propionates and Related Derivatives

Alkylation of 1-aryl-1H-1,2,4-triazol-3-ols with ethyl 2-bromopropionate under basic conditions resulted in the formation of 2-propionic acid, ethyl esters.No N-alkylated products were detected.Similar alkylation of 2-oxo-5-phenyl-1,3,4-thiazole and the corresponding 1,3,4-oxadiazole gave only N-alkylated derivatives.With 4-hydroxy-6-phenylpyrimidine and 2-oxo-4-phenylthiazole, both O- and N-alkylation occurred.Structure assignments were based on ir and 13C nmr spectral data.