40018-42-6

Basic information

• Product Name: 7-bromo-3-phenyl-4H-1,2,4-benzothiadiazine-1,1-dioxide
• Synonyms: 7-bromo-3-phenyl-4H-1,2,4-benzothiadiazine-1,1-dioxide
• CAS NO: 40018-42-6
• Molecular Weight: 337.197
• Mol File: 40018-42-6.mol

Chemical Properties

• CAS DataBase Reference: 7-bromo-3-phenyl-4H-1,2,4-benzothiadiazine-1,1-dioxide(CAS DataBase Reference)
• NIST Chemistry Reference: 7-bromo-3-phenyl-4H-1,2,4-benzothiadiazine-1,1-dioxide(40018-42-6)
• EPA Substance Registry System: 7-bromo-3-phenyl-4H-1,2,4-benzothiadiazine-1,1-dioxide(40018-42-6)

Safety Data

• Hazardous Substances Data: 40018-42-6(Hazardous Substances Data)

Upstream product

• 18818-44-5 3-Phenyl-2H-1,2,4-benzothiadiazine 1,1-dioxide 
• 23886-64-8 2,5-dibromobenzenesulfonyl chloride 
• 618-39-3 benzamidin 
• 1310552-60-3 N-amino(phenyl)methylene-2,5-dibromo-1-benzenesulfonamide 
• 54734-84-8 2-amino-5-bromobenzenesulfonamide 
• 108-88-3 toluene 

Relevant articles and documents

Metal-free sequential dual oxidative amination of C(sp3)–H bonds: A direct approach to benzothiadiazine 1,1-dioxide derivatives

An efficient and metal-free Di-tert-butyl peroxide (DTBP)-promoted dual oxidative amination annulation of 2-amino arylsulfonamide with methylarene has been developed. This protocol provides straightforward access to benzothiadiazine 1,1-dioxide derivatives without using prefunctionalized substrates in good to excellent yields with good functional group tolerance.

Facile synthesis of 4H-1,2,4-benzothiadiazine-1,1-dioxides

o-Bromoarylsulfonylated amidines prepared either by acylation of amidine with o-bromoarylsulfonyl chloride or through the reaction of o-bromoarylsulfoamide with lactime ether underwent Cu(I)-catalyzed intramolecular cyclization to give 4H-1,2,4-benzothiadiazine-1,1-dioxides in good yield. By varying substituents on arylsulfonyl moieties, amidines, and lactime ethers, a small library of structurally diverse 4H-1,2,4- benzothiadiazine-1,1-dioxide derivatives was prepared.

Novel compounds and their use as positive AMPA receptor modulators

The invention provides novel compounds represented by the general formula 5 compound represented by the formula: wherein the bond represented by the broken line may be a single, a double bond or absent; and if the bond is absent, then the nitrogen is substituted with a hydrogen and R2; X represents SO2 or C═O or CH2; Y represents —CH(R4)—, —N(R4)— or —N(R4)—CH2—, O; and the meaning of R2, R3, R4, R5, R6, R7, and R8 are as defined in the application The compounds are useful as positive modulators of the AMPA-receptor.