23894-60-2Relevant academic research and scientific papers
Synthesis and evaluation of pyrazolone compounds as SARS-coronavirus 3C-like protease inhibitors
Ramajayam,Tan, Kian-Pin,Liu, Hun-Ge,Liang, Po-Huang
experimental part, p. 7849 - 7854 (2011/02/23)
A series of pyrazolone compounds as possible SARS-CoV 3CL protease inhibitors were designed, synthesized, and evaluated by in vitro protease assay using fluorogenic substrate peptide in which several showed potent inhibition against the 3CL protease. Interestingly, one of the inhibitors was also active against 3C protease from coxsackievirus B3. These inhibitors could be potentially developed into anti-coronaviral and anti-picornaviral agents.
Utility of 1-(2,4-dimethoxyphenyl)-3-aryl-prop-2-ene-1-ones as ring transformer in preparing heterocyclic compounds and their potential biological activities
Salem,Soliman,Smith,Mahmoud,Azab
, p. 61 - 76 (2007/10/03)
As an effort to synthesize new heterocyclic compounds, which would be expected to have a pharmacological and biological activities, we report here the reactivity of 1-(2,4-dimethoxyphenyl)-3-aryl-2-propen-1-ones (Ia&b), as Michael acceptors under differen
