239066-84-3Relevant articles and documents
Glucocortiocoid-selective antinflammatory agents
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, (2008/06/13)
Compounds having Formula I are useful for partially or fully antagonizing, repressing, agonizing, or modulating the glucocorticoid receptor and treating immune, autoimmune and inflammatory diseases in a mammal. Also disclosed are pharmaceutical compositions comprising compounds of Formula I and methods of inhibiting immune or autoimmune diseases in a mammal.
Synthesis and characterization of non-steroidal ligands for the glucocorticoid receptor: Selective quinoline derivatives with prednisolone-equivalent functional activity
Coghlan,Kym,Elmore,Wang,Luly,Wilcox,Stashko,Lin,Miner,Tyree,Jacobson,Nakane,Lane
, p. 2879 - 2885 (2007/10/03)
A novel class of functional ligands for the human glucocorticoid receptor is described. Substituents in the C-10 position of the tetracyclic core are essential for glucocorticoid receptor (GR) selectivity versus other steroid receptors. The C-5 position i