239101-33-8

Basic information

• Product Name: Deferitrin
• Synonyms: Deferitrin;Deferitrin (GT-56-252);4,5-Dihydro-2-(2,4-dihydroxyphenyl)-4-methylthiazol-4-(S)-carboxylic acid;GT 56-252
• CAS NO: 239101-33-8
• Molecular Formula: C₁₁H₁₁NO₄S
• Molecular Weight: 253.277
• Mol File: 239101-33-8.mol
• Article Data: 2

Chemical Properties

• Melting Point: 281-283℃ (decomposition)
• Appearance: /
• CAS DataBase Reference: Deferitrin(CAS DataBase Reference)
• NIST Chemistry Reference: Deferitrin(239101-33-8)
• EPA Substance Registry System: Deferitrin(239101-33-8)

Safety Data

• Hazardous Substances Data: 239101-33-8(Hazardous Substances Data)

Usage

Uses

Deferitrin is a tridentate oral chelator intended for use in the primary treatment of iron overload resulting from transfusion therapy.

Upstream product

• 64419-24-5 2,4-dihydroxybenzonitrile 
• 76045-30-2 (S)-4,5-dihydro-2-(3-hydroxy-2-pyridinyl)-4-methyl-4-thiazolecarboxylic acid 
• 627101-38-6 4,5-dihydro-2-(2,4-dihydroxyphenyl)-4-methylthiazole-4(S)-carboxylic acid 

Downstream Products

• 887471-62-7 (S)-4,5-dihydro-2-(2-hydroxy-4-(3,6,9-trioxadecyloxy)phenyl)-4-methyl-4-thiazolecarboxylic acid 
• 887471-65-0 (S)-4'-(HO)-DADFT-PE iPrE 
• 887471-66-1 ethyl (S)-4,5-dihydro-2-[2-hydroxy-4-(3,6,9-trioxadecyloxy)phenyl]-4-methyl-4-thiazolecarboxylate 
• 887471-64-9 isopropyl (S)-2-(2,4-dihydroxyphenyl)-4,5-dihydro-4-methyl-4-thiazolecarboxylate 
• 847829-15-6 ethyl (S)-2-(2,4-dihydroxyphenyl)-4,5-dihydro-4-methyl-4-thiazolecarboxylate 
• 847829-19-0 ethyl (S)-4,5-dihydro-2-[2-hydroxy-4-[12-(tert-butoxycarbonylamino)-5,9-bis(tert-butoxycarbonyl)-5,9-diazadodecyloxy]phenyl]-4-methyl-4-thiazolecarboxylate 
• 847829-20-3 (S)-4,5-dihydro-2-[2-hydroxy-4-[12-(tert-butoxycarbonylamino)-5,9-bis(tert-butoxycarbonyl)-5,9-diazadodecyloxy]phenyl]-4-methyl-4-thiazolecarboxylic acid 
• 857941-15-2 ethyl (S)-4,5-dihydro-2-[2-hydroxy-4-[8-(tert-butoxycarbonylamino)-5-(tert-butoxycarbonyl)-5-azaoctyloxy]phenyl]-4-methyl-4-thiazolecarboxylate 
• 857941-87-8 (S)-4,5-dihydro-2-[2-hydroxy-4-[8-(tert-butoxycarbonylamino)-5-(tert-butoxycarbonyl)-5-azaoctyloxy]phenyl]-4-methyl-4-thiazolecarboxylic acid 
• 857941-17-4 ethyl (S)-4,5-dihydro-2-[2-hydroxy-4-[4-(tert-butoxycarbonylamino)butoxy]phenyl]-4-methyl-4-thiazolecarboxylate 
• 857941-18-5 (S)-4,5-dihydro-2-[2-hydroxy-4-[4-(tert-butoxycarbonylamino)butoxy]phenyl]-4-methyl-4-thiazolecarboxylic acid 

Relevant articles and documents

Synthesis of benzonitriles from substituted benzaldehyde

There is a significant demand for organic nitriles, based on their versatility in reactions. Compounds prepared from nitriles have properties including superoxide inhibition, ferrielectric liquid crystal dopant, antipicornaviral agents, anti-inflammatory agents, anti-asthma agents, and fibringoen antagonists. The present invention discloses a facile synthesis for 2,4-dihydroxybenzonitrile, and ethers and diethers thereof, from 2,4-dihydroxybenzaldehyde or 2,4-dimethoxybenzaldehyde. The present invention also discloses a method of preparing a class of iron chelating agents related to desferrithiocin, all of which contain a thiazoline ring. In this method, 2,4-dihydroxybenzonitrile is condensed with (S)-2-methylcysteine.