2392-48-5

Usage

Uses

Used in Chemical Synthesis:
4-chloro-1-(2,4-dichlorophenoxy)-2-nitrobenzene is used as a key intermediate in the synthesis of other chemical compounds and materials. Its specific structure and reactivity make it a valuable component in creating a range of products across different industries.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, 4-chloro-1-(2,4-dichlorophenoxy)-2-nitrobenzene is used as a precursor for the development of new drugs. Its unique chemical properties may contribute to the creation of novel therapeutic agents, potentially leading to advancements in medicine.
Used in Agricultural Industry:
4-chloro-1-(2,4-dichlorophenoxy)-2-nitrobenzene may also find applications in the agricultural industry, potentially serving as a component in the development of new agrochemicals. Its chemical structure could be harnessed to create innovative products for crop protection or enhancement of agricultural yields.

InChI:InChI=1/C12H6Cl3NO3/c13-7-1-3-11(9(15)5-7)19-12-4-2-8(14)6-10(12)16(17)18/h1-6H

Upstream product

• 120-83-2 2,4-dichlorophenol 
• 89-61-2 2,5-dichloronitrobenzene 
• 100125-34-6 5-chloro-2-(4-chloro-2-nitro-phenoxy)-benzenesulfonyl chloride 
• 59039-21-3 2,4,4'-Trichlorobiphenyl ether 

Downstream Products

• 120-83-2 2,4-dichlorophenol 
• 1422364-65-5 C₁₈H₁₂Cl₃NO₃S 
• 1274694-43-7 C₁₃H₁₀Cl₃NO 
• 1422364-63-3 C₁₃H₈Cl₃NO₂ 
• 69206-98-0 5-chloro-2-(2,4-dichloro-phenoxy)-benzoic acid 
• 2172-87-4 2.4.4'-Trichlor-2'-(dimethylamino)-diphenylether 
• 28076-73-5 2,2',4,4'-tetrachlorodiphenylether 
• 56966-52-0 5-Chloro-2-(2',4'-dichlorophenoxy)aniline 

Relevant academic research and scientific papers

The hydrogen reduction synthesis of 2, 4, 4 '- trichloro -2' - amino diphenyl ether (by machine translation)

The invention discloses a hydrogenation reduction synthesis of 2, 4, 4 '- trichloro - 2' - amino-diphenyl ether, will be 2, 4, 4 '- trichloro - 2' - nitro-diphenyl ether in a solvent, adding catalyst, dechlorination inhibitors, hydrogen, thermal insulation reaction, after the reaction, the catalyst precipitation separation, synthetic fluid desolution, rectification, to obtain 2, 4, 4 '- trichloro - 2' - diaminodiphenyl ether. The invention hydrogenation after reduction, dechlorination product content can be controlled in a 0.2% the following, through the rectification under a reduction product, the quality of the target product can be obtained. (by machine translation)

Novel diaryl ureas with efficacy in a mouse model of malaria

Exploration of triclosan analogs has led to novel diaryl ureas with significant potency against in vitro cultures of drug-resistant and drug-sensitive strains of the human malaria parasite Plasmodium falciparum. Compound 18 demonstrated EC50 values of 37 and 55 nM versus in vitro cultured parasite strains and promising in vivo efficacy in a Plasmodium berghei antimalarial mouse model, with >50% survival at day 31 post-treatment when administered subcutaneously at 256 mg/kg. This series of compounds provides a chemical scaffold of novel architecture, as validated by cheminformatics analysis, to pursue antimalarial drug discovery efforts.

A PROCESS FOR THE PREPARATION OF 5-CHLORO-2(2,4-DICHLOROPHENOXY) ANILINE

A novel process for the selective reduction of halonitroarenes in general and halonitroaromatic arenes in particular, without the hydrogenolysis of the C-Cl (where, X represents F-, Cl-, Br- and I) and the C-O-C bonds, in the presence of platinum based catalysts and ammonium formate. The invention makes the use of duel function of ammonium formate, as a hydrogen source for partial reduction (catalytic transfer hydrogenation) and as an additive controlling the hydrogenolysis side reactions during the completion of the reduction by high pressure catalytic hydrogenation using external hydrogen gas source. Uniqueness of the invention lies in the fact that either the catalytic transfer hydrogenation with ammonium formal e or high pressure catalytic hydrogenation in the absence of ammonium formate, when used alone result in lower purity of the said amine. This invention -product is used to synthesize intermediates for making antibacterial compounds.