23941-84-6

Basic information

• Product Name: 1,3,6-TRIMETHYL-2,4-DIOXO-1,2,3,4-TETRAHYDRO-PYRIMIDINE-5-CARBALDEHYDE
• Synonyms: AKOS BC-1635;1,3,6-TRIMETHYL-2,4-DIOXO-1,2,3,4-TETRAHYDRO-PYRIMIDINE-5-CARBALDEHYDE
• CAS NO: 23941-84-6
• Molecular Formula: C₈H₁₀N₂O₃
• Molecular Weight: 182.18
• Mol File: 23941-84-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 283.2°Cat760mmHg
• Flash Point: 123°C
• Appearance: /
• Density: 1.325g/cm³
• Vapor Pressure: 0.00321mmHg at 25°C
• Refractive Index: 1.586
• Storage Temp.: 2-8°C
• PKA: -3.02±0.60(Predicted)
• CAS DataBase Reference: 1,3,6-TRIMETHYL-2,4-DIOXO-1,2,3,4-TETRAHYDRO-PYRIMIDINE-5-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3,6-TRIMETHYL-2,4-DIOXO-1,2,3,4-TETRAHYDRO-PYRIMIDINE-5-CARBALDEHYDE(23941-84-6)
• EPA Substance Registry System: 1,3,6-TRIMETHYL-2,4-DIOXO-1,2,3,4-TETRAHYDRO-PYRIMIDINE-5-CARBALDEHYDE(23941-84-6)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 23941-84-6(Hazardous Substances Data)

Usage

General Description

1,3,6-Trimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde is a chemical compound with the molecular formula C9H12N2O3. It is a pyrimidine-5-carbaldehyde derivative and is used in various chemical and pharmaceutical applications. The compound is known for its potential as an intermediate in the synthesis of bioactive compounds and has been studied for its potential pharmacological properties. It is used in the production of drugs, molecular markers, and other bioactive compounds. The compound's unique structure and properties make it valuable for chemical research and development, and it has potential applications in the pharmaceutical and biomedical industries.

InChI:InChI=1/C8H10N2O3/c1-5-6(4-11)7(12)10(3)8(13)9(5)2/h4H,1-3H3

Upstream product

• 626-48-2 6-Methyluracil 
• 13509-52-9 1,3,6-trimethyluracil 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 132092-79-6 1,3,6-Trimethyl-5-[(E)-phenyliminomethyl]-1H-pyrimidine-2,4-dione 
• 117175-85-6 1,3-dimethyl-7-phenyl-6-(1',2',3',4'-tetrahydro-1',3',6'-trimethyl-2',4'-dioxopyrimidin-5'-yl)pyrido<3,4-d>pyrimidine-2,4(1H,3H)-dione 

Relevant articles and documents

Aminocatalytic Synthesis of Uracil Derivatives Bearing a Bicyclo[22.2]octane Scaffold via a Doubly Cycloadditive Reaction Cascade

Aminocatalytic synthesis of highly enantiomerically enriched uracil derivatives bearing a bicyclo[2.2.2]octane scaffold is described. The developed strategy utilizes 1,3,6-trimethyl-5-formyluracil and α,β-unsaturated aldehydes as starting materials and has been realized employing various aminocatalytic activation strategies operating in a synergistic manner. The reaction cascade can be described as doubly cycloadditive as it consists of two consecutive Diels-Alder cycloadditions allowing for a facile construction of the bicyclo[2.2.2]octane scaffold. Notably, both steps proceed with dearomatization of the partially aromatic uracil moiety. Excellent stereoselectivity of the reaction cascade is ensured by the use of 2-(diphenylmethyl)pyrrolidine as aminocatalyst.

PYRIMIDINEDIONE-FUSED HETEROCYCLIC COMPOUNDS AS TRPA1 MODULATORS

The present invention is related to novel pyrimidinedione-fused heterocyclic compounds as TRPA (Transient Receptor Potential subfamily A) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPA1 (Transient Receptor Potential subfamily A, member 1). Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPA1.