23942-11-2

Usage

Uses

Used in Pharmaceutical Synthesis:
2-amino-5-benzyl-6-methyl-1H-pyrimidin-4-one is utilized as a key building block for the creation of various bioactive molecules and pharmaceuticals. Its unique structure allows for the development of compounds with specific therapeutic properties, making it an essential component in medicinal chemistry.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 2-amino-5-benzyl-6-methyl-1H-pyrimidin-4-one serves as a structural foundation for designing new drugs. Its heterocyclic nature and substituents enable the exploration of different chemical modifications, potentially leading to the discovery of novel therapeutic agents.
Used in Drug Discovery:
2-amino-5-benzyl-6-methyl-1H-pyrimidin-4-one is also employed in drug discovery processes, where its potential biological activities are investigated. This can involve screening for interactions with specific biological targets or assessing its efficacy in treating certain diseases, thereby contributing to the advancement of new treatment options.

Upstream product

• 50-01-1 guanidine hydrochloride 
• 620-79-1 Ethyl 2-benzylacetoacetate 
• 124-46-9 guanidine hydrogen carbonate 

Downstream Products

• 162272-61-9 5-benzyl-4-chloro-6-methyl-pyrimidin-2-ylamine 

Relevant academic research and scientific papers

Direct synthesis of 5- and 6-substituted 2-aminopyrimidines as potential non-natural nucleobase analogues

A series of 2-aminopyrimidine derivatives, substituted at 5- and 6-positions, were synthesized. The reaction was carried out in a single step by treatment of the corresponding β-ketoester or β-aldehydoester with guanidine hydrochloride in the presence of K2CO3, in a microwave-assisted method without the requirement of solvent. A unique 1:1 co-crystal structure was obtained which shows that a 6-phenyl-2- aminopyrimidinone forms a strong nucleobase-pair with cytosine, involving three hydrogen bonds. The base-pair was found to be as strong as that of natural guanine:cytosine (G:C), signifying the potential application of the synthesized derivatives. Additionally, we also report a second co-crystal involving 5-isopropyl-6-methyl-2-aminopyrimidinone and cytosine in a 1:1 ratio, which also shows strong base-pairing properties. the Partner Organisations 2014.

Bicyclic pyrimidine compounds and therapeutic use thereof

A pyrimidine derivative of the formula (1) or a salt thereof; has an inhibitory activity of production of Th2 type cytokines such as IL-4, IL-5, etc., and is useful as an therapeutic agent for allergic diseases, autoimmune diseases such as systemic lupus erythemathosus, etc., and acquired immunodeficiecy syndrome (AIDS) and so on.