23942-38-3Relevant academic research and scientific papers
A Green synthesis of pyrrolo[1,2-a]quinazolin-5(1H)-one derivatives in ionic liquids catalyzed by iodine
Zhou, Jie-Xing,Lu, Lian,Li, Tuan-Jie,Yao, Chang-Sheng,Wang, Xiang-Shan
, p. 1472 - 1475 (2015/04/27)
A series of 2,3,3a,4-tetrahydro-3a-methylpyrrolo[1,2-a]quinazolin-5(1H)-one derivatives were synthesized by a reaction of 2-aminobenzamide and 5-chloropentan-2-one at 80 °C catalyzed by iodine in ionic liquid of [BMIm]Br. Compared with the other methods, this novel method has the advantages of milder reaction conditions, high yields, environmental benignity, and metal-free catalyst. A series of 2,3,3a,4-tetrahydro-3a-methylpyrrolo[1,2-a]quinazolin-5(1H)-one derivatives were synthesized by a reaction of 2-aminobenzamide and 5-chloropentan-2-one at 80 °C catalyzed by iodine in ionic liquid of [BMIm]Br.
Efficient and convenient synthesis of pyrrolo[1,2- a ]quinazoline derivatives with the aid of tin(II) chloride
Wang, Manman,Dou, Guolan,Shi, Daqing
experimental part, p. 582 - 586 (2010/09/04)
An efficient, convenient, one-pot synthesis of 2,3,3a,4- tetrahydropyrrolo[1,2-a]quinazolin-5(1H)-one and 2,3,3a,4-tetrahydropyrrolo[1,2- a]quinazoline-1,5-dione was accomplished in good yields via the novel reductive cyclization of 2-nitrobenzamides with haloketones or keto acids mediated by SnCl22H2O system. A variety of substrates can participate in the process with good yields, making this methodology suitable for library synthesis in drug discovery efforts.
