239465-99-7

Upstream product

• 126354-04-9 O-(2-Acetamido-3,4,6-tri-O-acetyl-2-desoxy-β-D-glucopyranosyl)-(1->2)-3,4,6-tri-O-acetyl-D-mannopyranose 
• 108-98-5 thiophenol 
• 122210-05-3 1,3,4,6-tetra-O-acetyl-2-deoxy-2-(2,2,2-trichloroethoxycarbonylamino)-β-D-glucopyranose 
• 108-24-7 acetic anhydride 
• 168138-26-9 phenyl 4,6-O-benzylidene-3-O-(4-methoxybenzyl)-1-thio-α-D-mannopyranoside 
• 159407-19-9 phenyl 4,6-O-benzylidene-1-thio-α-D-mannopyranoside 

Downstream Products

• 239466-01-4 N-[2-(4,5-dihydroxy-6-hydroxymethyl-2-phenylsulfanyl-tetrahydro-pyran-3-yloxy)-4-hydroxy-6-hydroxymethyl-5-(3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-3-yl]-acetamide 
• 239466-00-3 N-[(2S,3R,4R,5S,6R)-2-((2R,3S,4S,5S,6R)-4,5-Dihydroxy-6-hydroxymethyl-2-phenylsulfanyl-tetrahydro-pyran-3-yloxy)-4,5-dihydroxy-6-hydroxymethyl-tetrahydro-pyran-3-yl]-acetamide 

Relevant academic research and scientific papers

Facile Chemoenzymatic Synthesis of O-Mannosyl Glycans

O Mannosylation is a vital protein modification involved in brain and muscle development whereas the biological relevance of O-mannosyl glycans has remained largely unknown owing to the lack of structurally defined glycoforms. An efficient scaffold synthe

The first synthesis of Neu5Acα2-3Galβ1-4GlcNAcβ1-2Manα1-Ser a newly discovered component of α-dystroglycan

Glycopeptide (1), Neu5Acα2-3Galβ1-4GlcNAcβ1-2Manα1-Ser, was synthesized using a chemoenzymatic strategy. Galβ1-4GlcNAcβ1-2Man trisaccharide was prepared using glycosidase assisted oligosaccharide synthesis. After coupling of this trisaccharide with a serine derivative by chemical glycosylation, sialic acid was introduced using sialyltransferase to produce a tetrasaccharide serine derivative. Removal of protecting group afforded glycopeptide (1). Use of a chemoenzymatic strategy allowed for the elimination of numerous synthetic steps and efficient preparation of the target compound.