168138-26-9

Upstream product

• 824-94-2 p-methoxybenzyl chloride 
• 159407-19-9 phenyl 4,6-O-benzylidene-1-thio-α-D-mannopyranoside 
• 2746-25-0 p-Methoxybenzyl bromide 
• 108-98-5 thiophenol 
• 83-87-4 D-Mannose pentaacetate 
• 13992-16-0 phenyl 2,3,4,6-tetra-O-acetyl-1-thio-α-D-mannopyranoside 
• 2936-70-1 (2R,3S,4S,5S,6R)-2-Hydroxymethyl-6-phenylsulfanyl-tetrahydro-pyran-3,4,5-triol 
• 1125-88-8 benzaldehyde dimethyl acetal 

Downstream Products

• 168138-14-5 phenyl 3-O-(4-methoxybenzyl)-1-thio-α-D-mannopyranoside 
• 177943-74-7 methyl 2-O-benzyl-4,6-O-benzylidene-3-O-p-methoxybenzyl-1-thio-α-D-mannopyranoside 
• 256413-55-5 tert-Butyl-[(2R,4aR,6R,7S,8S,8aR)-8-(4-methoxy-benzyloxy)-2-phenyl-6-phenylsulfanyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yloxy]-dimethyl-silane 
• 855306-29-5 phenyl 4,6-O-benzylidene-2-O-allyl-3-O-p-methoxybenzyl-1-thio-α-D-mannopyranoside 
• 855306-32-0 phenyl 4,6-O-benzylidene-2-O-(prop-2-ynyl)-3-O-p-methoxybenzyl-1-thio-α-D-mannopyranoside 
• 855306-30-8 phenyl 4,6-O-benzylidene-2-O-allyl-1-thio-α-D-mannopyranoside 
• 855306-33-1 phenyl 4,6-O-benzylidene-2-O-(prop-2-ynyl)-1-thio-α-D-mannopyranoside 
• 855306-31-9 phenyl 4,6-O-benzylidene-2-O-allyl-3-O-(tert-butyldimethylsilyl)-1-thio-α-D-mannopyranoside 
• 855306-34-2 phenyl 4,6-O-benzylidene-2-O-(prop-2-ynyl)-3-O-(tert-butyldimethylsilyl)-1-thio-α-D-mannopyranoside 
• 855306-38-6 methyl 4-O-[4,6-O-benzylidene-2-O-(prop-2-ynyl)-3-O-tert-butyldimethylsilyl-β-D-mannopyranosyl]-(1->4)-2,3-O-isopropylidene-α-L-rhamnopyranoside 
• 855306-48-8 phenyl 4,6-O-benzylidene-2-O-(prop-2-ynyl)-3-O-(2,3-di-O-benzyl-4,6-O-benzylidene-β-D-mannopyranosyl)-1-thio-α-D-mannopyranoside 
• 855306-41-1 methyl 2,3,6-tri-O-benzyl-4-O-[4,6-O-benzylidene-2-O-(prop-2-ynyl)-3-O-tert-butyldimethylsilyl-β-D-mannopyranosyl]-(1->4)-α-D-glucopyranoside 
• 855306-36-4 3β-cholestanyl 4,6-O-benzylidene-2-O-(prop-2-ynyl)-3-O-tert-butyldimethylsilyl-β-D-mannopyranoside 

Relevant academic research and scientific papers

Facile Chemoenzymatic Synthesis of O-Mannosyl Glycans

O Mannosylation is a vital protein modification involved in brain and muscle development whereas the biological relevance of O-mannosyl glycans has remained largely unknown owing to the lack of structurally defined glycoforms. An efficient scaffold synthe

A Synthetic Carbohydrate-Protein Conjugate Vaccine Candidate against Klebsiella pneumoniae Serotype K2

Klebsiella pneumoniae causes pneumonia and liver abscesses in humans worldwide and contains virulence factor capsular polysaccharides and lipopolysaccharides linked to the cell wall. Although capsular polysaccharides are good antigens for vaccine producti

ANTIBODY CONJUGATES AND METHODS OF MAKING THE ANTIBODY CONJUGATES

Described herein are antibody conjugates and methods of making antibody conjugates.

Direct chemical synthesis of the β-mannans: Linear and block syntheses of the alternating β-(1→3)-β-(1→4)-mannan common to Rhodotorula glutinis, Rhodotorula mucilaginosa, and Leptospira biflexa

Two stereocontrolled syntheses of a methyl glycoside of an alternating β-(1→4)-β-(1→3)-mannohexaose, representative of the mannan from Rhodotorula glutinis, Rhodotorula mucilaginosa, and Leptospira biflexa, are described. Both syntheses employ a combinati

Total synthesis of everninomicin 13,384-1 - Part 3: Synthesis of the DE fragment and completion of the total synthesis

The stereoselective construction of the DE fragment (2) of everninomicin 13,384-1 (1) is reported. From the two possible ways of inserting the DE fragment between the A1B(A)C and FGHA2 domains of the natural product, the sequence involving the DEFGHA2 segment was found to be the most viable. This coupling was followed by attachment of a suitably protected and activated A1B(A)C fragment which led, after orthoester construction and final deprotection to the targeted everninomicin 13,384-1 (1), completing the total synthesis of this complex naturally occurring substance.

A synthetic approach to the glycan chain of high mannose type N-glycoprotein

The syntheses of α-D-glucopyranose-(1→3)-D-mannopyranose, methyl α-D-glucopyranose-(1→3)-α-D-mannopyranoside and methyl α-D-glucopyranose-(1→3)-α-D-mannopyranose-(1→2)-α-D- mannopyranoside are reported. High stereoselectivity was observed during the coupl

Synthesis of 2-O-(3-O-carbamoyl-α-D-mannopyranosyl)-L-gulopyranose: Sugar moiety of antitumor antibiotic bleomycin

A new route to the disaccharide moiety (2-O-(3-O-carbamoyl-α-D-mannopyranosyl)-L-gulopyranose) of the antitumor agent bleomycin was developed. Both the L-gulose synthon 21 and the 3-O-carbamoyl-D-mannose segment 30 were prepared from D-mannose in a regioselective manner by applying stannylene acetal methodology. Glycosylation of 21 with 30 proceeded smoothly, and further conversion to disaccharide derivatives (33 and 34) was successfully accomplished.

Preparation of 2-O-(3-O-carbamoyl-α-D-mannopyranosyl)-L-gulopyranose: Synthetic study on the sugar moiety of antitumor antibiotic bleomycin

A new practical route to the disaccharide moiety of bleomycin was developed. Both of key building blocks 9 and 16 were prepared from D-mannose in a regioselective manner by applying stannylene acetal methodology. Glycosylation of the allyl alcohol 9 with the trichloroacetimidate 16 proceeded smoothly, and the further incorporation to the disaccharide moiety was succesfully accomplished.