23947-29-7Relevant academic research and scientific papers
A regioselective synthesis of tetrahydrobenzodiazepin-5-ones via the Schmidt rearrangement of quinolones
Tapia, Ricardo A.,Centella, Cesar
, p. 2757 - 2765 (2004)
The regioselective synthesis of 2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-5- ones by the Schmidt rearrangement of 1,2,3,4-tetrahydro-4-quinolones with oxygen substituents at C-8 is described.
ANTIVIRAL COMPOUNDS
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Paragraph 0438, (2018/04/13)
The present invention relates to novel compounds of general formula (I) wherein the groups X, and R1 to R4 have the meanings given in the description and claims, process for preparing these compounds and their use as for treating, preventing or ameliorating viral infections and their use for treating, preventing or ameliorating diseases which are associated with PLA2G16.
β-Cyclodextrin promoted aza-Michael addition of amines to conjugated alkenes in water
Surendra,Krishnaveni, N. Srilakshmi,Sridhar,Rao, K. Rama
, p. 2125 - 2127 (2007/10/03)
Highly efficient and environmentally benign aza-Michael additions of amines to α,β-unsaturated compounds catalyzed by β-cyclodextrin in water to produce the corresponding β-amino compounds in excellent yields under mild conditions are described. β-Cyclodextrin can be recovered and reused in subsequent reactions without loss of activity.
Fast, easy, solvent-free, microwave-promoted Michael addition of anilines to α,β-unsaturated alkenes: synthesis of N-aryl functionalized β-amino esters and acids
Amore, Kristen M.,Leadbeater, Nicholas E.,Miller, Tyson A.,Schmink, Jason R.
, p. 8583 - 8586 (2007/10/03)
The rapid, simple, microwave-promoted synthesis of N-aryl functionalized β-amino esters using Michael addition reactions is presented. Reactions are performed neat at 200 °C for 20 min and are catalyzed by acetic acid. The esters can be easily hydrolyzed to the corresponding N-aryl functionalized β-amino acids.
Structure-activity relationships of antimalarial indoloquinolines
Werbel, L. M.,Kesten, S. J.,Turner, W. R.
, p. 837 - 852 (2007/10/02)
Structure-activity relationships have been ascertained and chemical metodology developed for a series of antimalarial 3-chloroindoloquinoline-5-oxides.The basic side chain as well as the ring N-oxide are critical for antimalarial activity as is a bromine or chlorine in position 3.Substitution at positions 7,8,9,10 in not essential, although the most potent analog in our studies was the 8-nitro compound 4vv. indoloquinolines / antimalarial agents
