239477-77-1

Upstream product

• 108-30-5 succinic acid anhydride 
• 16874-17-2 L-phenylalanine tert-butyl ester 
• 15100-75-1 L-phenylalanine tert-butyl ester hydrochloride 

Downstream Products

• 1609283-85-3 C₅₆H₆₂N₄O₁₃ 
• 1609283-87-5 C₄₄H₄₉N₃O₁₁ 
• 1609283-27-3 C₃₅H₃₃N₃O₉ 
• 1609283-25-1 C₄₈H₄₆N₄O₁₃ 
• 1054668-72-2 5'-O-(N-<4-<(butoxycarbonyl-2-phenylethyl)amino>-4-oxobutanoyl>aminopropanoyl)-N³-(p-methoxybenzyl)-2',3'-O-isopropylideneuridine 

Relevant academic research and scientific papers

3-SUBSTITUTED PIPERIDINE-2, 6-DIONES AND NON-COVALENT COMPLEXES WITH ALBUMIN

The present disclosure provides derivatives of 3-substituted piperidine-2, 6-diones, non-covalently bound complexes with serum albumin, pharmaceutical compositions of the same, and methods of use thereof. The non-covalently bound complexes are significant

Novel Analogs of Camptothecin

The present invention provides novel conjugates of camptothecin and camptothecin analogs with a linker and an HSA-binding moiety. The novel conjugates are prodrug forms of the camptothecin or camptothecin analogs and can be used to treat mammalian cell pr

SOLUBLE COMPLEXES OF DRUG ANALOGS AND ALBUMIN

The present invention provides novel, non-covalently bound complexes of serum albumin and analogs of poorly soluble drugs, such as camptothecin. The novel complexes are significantly more water-soluble than the camptothecin analogs and are useful as prodr

Structure-function studies on nucleoside antibiotic mureidomycin A: Synthesis of 5′-functionalised uridine models

The importance of functional groups in nucleoside antibiotic mureidomycin A (MRD A) for biological activity has been examined by derivatisation of samples of the natural product, and by synthesis of uridine-containing analogues. N-Succinyl and di- and tri-acetyl derivatives MRD A have been prepared, and were found to have reduced activity as inhibitors of E. coli translocase I. The enamide alkene of MRD A was found to be extremely resistant towards hydrogenation by a variety of reagents. Several 5′-functionalised uridine derivatives were synthesised from N3-p-methoxybenzyl-2′,3′-isopropylideneuridine. A series of 5′-aminoacyl derivatives were prepared, and the 3-aminopropionyl (IC50 260 μM) and 7-aminoheptanoyl (IC50 1.5 mM) derivatives were found to act as reversible inhibitors. An analogue mimicking the carboxy terminus of MRD A was synthesised, and also acted as an inhibitor of translocase I (IC50 1.9 mM). A phosphonate analogue designed as a possible suicide inhibitor showed modest inhibition (IC50 3.7 mM), which was shown to be irreversible.