2396-14-7Relevant academic research and scientific papers
Regiocontrolled Heptafluoroisopropylation of Aromatic Halides by Copper(I) Carboxylates with Heptafluoroisopropyl-Zinc Reagents
Ono, Soichiro,Yokota, Yuki,Ito, Shigekazu,Mikami, Koichi
supporting information, p. 1093 - 1097 (2019/05/16)
Copper(I)-mediated heptafluoroisopropylation of aryl halides (ArX: X = I, Br) is demonstrated using copper(I) carboxylates and a bis(heptafluoroisopropyl)zinc reagent Zn(i-C3F7)2(dmf)2, prepared from heptafluoroisopropyl iodide and diethylzinc. The air-tolerant solid heptafluoroisopropylzinc reagent is advantageous to conduct simple synthetic operations and successful to give the corresponding heptafluoroisopropyl arene derivatives via transmetalation to copper(I) center. The newly developed copper(I)-mediated heptafluoroisopropylation process can be advanced to the copper(I)-catalysis by silver carboxylate salts and complementary to the precedent radical-based processes.
A hexafluoropropylene directly to the aryl borate method of oxidation heptafluoro isopropylation
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Paragraph 0060-0066; 0143; 0144; 0145; 0146, (2016/10/20)
The invention relates to a method for directly oxidizing arylboronic acid into heptafluoroisopropyl by utilizing hexafluoropropylene. The method comprises the following steps that silver fluoride is used as a fluorine source, under the effect of copper salt, the hexafluoropropylene and the arylboronic acid can be converted into a series of compounds containing heptafluoroisopropyl in organic solvents at the room temperature, and the reaction is also applicable to alkenylboronic acids. The method has the advantage that a series of compounds containing the heptafluoroisopropyl are synthesized through one-step reaction at high selectivity.
Direct heptafluoroisopropylation of arylboronic acids via hexafluoropropene (HFP)
Li, Yajun,Wang, Xiaojun,Guo, Yuwei,Zhu, Zhentong,Wu, Yongming,Gong, Yuefa
supporting information, p. 796 - 799 (2016/01/12)
A novel and straightforward strategy for heptafluoroisopropylation of arylboronic acids at room temperature has been developed. This method, directly using commercial available hexafluoropropene (HFP) as the starting material, provides a new way to synthesize a variety of synthetically useful heptafluoroisopropylated arenes.
