116-15-4Relevant articles and documents
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Miller et al.
, p. 4159,4163 (1957)
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Husted,Kohlhase
, p. 5141,5143 (1954)
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Rogers,Cady
, p. 3523 (1951)
Dresdner et al.
, p. 5831,5832 (1960)
Steunenberg,Cady
, p. 4165 (1952)
Labelling of the CFC-alternative, 2H-heptafluoropropane (HFC 227ea), with fluorine-18
Aigbirhio, Franklin I.,Pike, Victor W.
, p. 67 - 74 (1995)
Various reactions of no-carrier-added K(+)-aminopolyether 2.2.2-fluoride were examined for labelling the CFC-alternative, 2H-heptafluoropropane (HFC 227ea), with the positron-emitting radioisotope, fluorine-18 (t1/2 = 109.7 min).Reaction with 2H-hexafluoroisopropyl tosylate incorporated less than 2percent of the radioactivity into HFC 227ea and about 12percent into three other volatile products.Reaction with hexafluoropropene led to a high incorporation of fluorine-18 (80percent) into four radioactive products, namely the desired HFC 227ea, hexafluoropropene, perfluoro-isohex-2-ene and an unknown, in a molar ratio of 5:4:38:3, respectively.Although reaction with 1-iodo-2H-hexafluoropropane gave HFC 227ea in a much higher radiochemical yield (50percent decay-corrected), the best radiochemical yield (80percent decay-corrected) was obtained by exchange with HFC 227ea.The mechanistic bases of the results are discussed.An efficient fully shielded and automated procedure was devised for labelling HFC 227ea with fluorine-18 in high radioactivity, based on the successful exchange reaction and GC purification. HFC 227ea was obtained in high radiochemical purity (>99percent) and high chemical purity (>98.4percent) at 80 min from the start of radiosynthesis.This product is suitable for studies of the disposition of HFC 227ea in vivo. - Keywords: 2H-Heptafluoropropane; HFC 227ea; Fluorine-18; Exchange labelling; Mass spectrometry; Reaction mechanisms
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Tarrant,P.,Savory,J.
, p. 1728 - 1730 (1963)
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Perfluoroalkyl Grignard Reagents: NMR Study of 1-Heptafluoropropylmagnesium Chloride in Solution
Guang, Jie,Hopson, Russell,Williard, Paul G.,Fujiu, Motohiro,Negishi, Kazuyuki,Mikami, Koichi
, p. 5922 - 5928 (2016)
We report on the generation of a perfluoroalkyl Grignard reagent (FRMgX) by exchange reaction between a perfluoroalkyl iodide (FR-I) and a Grignard reagent (RMgX). 19F NMR was applied to monitor the generation of n-C3F7MgCl. Additional NMR techniques, including 19F COSY, NOESY, and pulsed gradient spin-echo (PGSE) diffusion NMR, were invoked to assign peaks observed in 19F spectrum. Schlenk equilibrium was observed and was significantly influenced by solvent, diethyl ether, or THF.
Preparation of trifluoroiodomethane via vapor-phase catalytic reaction between hexafluoropropylene oxide and iodine
Yang, Guang-Cheng,Jia, Xiao-Qing,Pan, Ren-Ming,Quan, Heng-Dao
, p. 985 - 988 (2009)
Based on our previous investigation on the reaction mechanism to produce difluorocarbene and subsequent CF3I starting with CHF3 and I2, a new route for preparing CF3I at a relative low temperature, 200 °C, has b
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Haszeldine,Steele
, p. 1592,1597 (1953)
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Keller,Tarrant
, p. 297,298-299,302-303,305 (1975)
A novel and efficient synthetic route to perfluoroisobutyronitrile from perfluoroisobutyryl acid
Wang, Yi,Sun, Mengting,Gao, Zhanyang,Zou, Lilin,Zhong, Lingyu,Peng, Ruichao,Yu, Ping,Luo, Yunbai
, p. 37159 - 37164 (2018)
A novel synthetic route to perfluoroisobutyronitrile from perfluoroisobutyryl acid which has mild conditions and low toxicity is described. This study introduces detailed synthetic protocols and characterization including GC-MS, 13C NMR and 19F NMR spectroscopy of perfluoroisobutyryl acid, perfluoroisobutyryl chloride, perfluoroisobutyl amide and perfluoroisobutyronitrile. Besides, this route is superior to the established patent and shows potential application in high voltage electrical equipment.
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Dresdner et al.
, p. 698 (1959)
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Novel synthetic route to perfluoroallyl cyanide (PFACN) reacting perfluoroallyl fluorosulfonate with cyanide
Tverdomed, Sergey N.,Hirschberg, Markus E.,Pajkert, Romana,Hintzer, Klaus,R?schenthaler, Gerd-Volker
, p. 65 - 69 (2018/03/21)
A novel synthetic method for the preparation of perfluoroallyl cyanide CF2[dbnd]CFCF2CN (PFACN) is presented. This includes the addition – elimination reaction of cyanide anion with perfluoroallyl fluorosulfate CF2[dbnd]CF