116-15-4

Basic information

• Product Name: Perfluoro-1 -propene
• Synonyms: Propene,hexafluoro- (8CI);1,1,2,3,3,3-Hexafluoro-1-propene;1,1,2,3,3,3-Hexafluoropropene;Esafluoropropene;F 1216;HFC 1216;Hexafluoro-1-propene;Hexafluoropropene;Hexafluoropropylene;PFC 1216;Perfluoro-1-propene;Perfluoropropene;Perfluoropropylene;Propylene hexafluoride;R 1216
• CAS NO: 116-15-4
• Molecular Formula: C₃F₆
• Molecular Weight: 150.0225192
• EINECS: 204-127-4
• Mol File: 116-15-4.mol
• Article Data: 69

Chemical Properties

• Melting Point: -153℃
• Boiling Point: -28 ºC
• Flash Point: °C
• Appearance: colourless gas
• Density: 1.442 g/cm³
• Vapor Pressure: 4770mmHg at 25°C
• Refractive Index: 1.253
• CAS DataBase Reference: Perfluoro-1 -propene(CAS DataBase Reference)
• NIST Chemistry Reference: Perfluoro-1 -propene(116-15-4)
• EPA Substance Registry System: Perfluoro-1 -propene(116-15-4)

Safety Data

• Hazard Codes: Xn:Harmful
• Statements: R20:; R37:
• Safety Statements: S41:
• Hazardous Substances Data: 116-15-4(Hazardous Substances Data)

Usage

General Description

Perfluoro-1-propene, also known as Hexafluoropropene (HFP), is a chemical compound with a formula of C3F6. It is part of the family of fluoroalkenes, and is commonly utilized in various industrial applications due to its desirable properties. As a compound, HFP is colorless, with a faint, sweetish odor, and it can exist as a compressed liquefied gas. It exhibits high thermal stability and is nonflammable. However, it is noted for its potential to decompose under high temperatures to produce toxic and corrosive fumes. Hence, appropriate safety measures are necessary when handling this compound. Perfluoro-1-propene is commonly used in the production of fluoropolymers, refrigerants, and fire extinguishing agents.

InChI:InChI=1/C3F6/c4-1(2(5)6)3(7,8)9

Synthetic route

polytetrafluoroethylene (116-14-3) → perfluoropropylene (116-15-4)

Conditions	Yield
With silicon carbide at 450 - 850℃; for 3.33333E-05h;	96.5%
at 760 - 860℃; unter vermindertem Druck;
at 700℃; bei der thermischen Zersetzung;

(heptafluoro n-propyl) magnesiumiodide (423-25-6) → HFC-227ca (2252-84-8) + perfluoropropylene (116-15-4)

Conditions	Yield
In further solvent(s) decomposition on boiling in dibutyl ether;;	A 76% B 6%
In further solvent(s) decomposition on boiling in dibutyl ether;;	A 76% B 6%

(heptafluoro i-propyl) magnesiumbromide (662-13-5) → perfluoropropylene (116-15-4)

Conditions	Yield
In diethyl ether warming from -78 to 20°C and heating under reflux, 1 hour;;	70.5%
In diethyl ether warming from -78 to 20°C and heating under reflux, 1 hour;;	70.5%

perfluoro-2-methylpentan-3-one (756-13-8) → perfluoropropylene (116-15-4) + perfluoropropanoyl fluoride (422-61-7)

Conditions	Yield
With cesium fluoride at 250℃; for 2h; Product distribution;	A 68% B n/a

ethyl heptafluoroisobutyrate (1526-49-4) + phenyllithium (591-51-5) → perfluoropropylene (116-15-4) + benzoic acid ethyl ester (93-89-0) + perfluoroisopropyl phenyl ketone (56112-35-7)

Conditions	Yield
In diethyl ether at -110℃; for 0.166667h; C6H5Li added to ester;	A n/a B n/a C 65%

perfluorocetane (355-49-7) → polytetrafluoroethylene (116-14-3) + perfluoropropylene (116-15-4) + octafluoro-1-butene (357-26-6)

Conditions	Yield
at 195 - 500℃; under 75.7576 Torr; Temperature; Pressure; Pyrolysis;	A 62.4% B 24.3% C 6.2%

1,2-dibromohexafluoropropane (661-95-0) → 1-bromo-1,1,2,3,3,3-hexafluoro-propane (2252-78-0) + perfluoropropylene (116-15-4) + 1,1,1,2,3,3-hexafluoropropane (431-63-0) + 2-bromo-1,1,1,2,3,3-hexafluoro-propane (2252-80-4)

Conditions	Yield
With tri-n-butyl-tin hydride for 1.5h; Product distribution; Heating;	A 53% B 3% C 14% D 21%

perfluorocetane (355-49-7) → polytetrafluoroethylene (116-14-3) + perfluoropropylene (116-15-4)

Conditions	Yield
at 195 - 600℃; under 75.7576 Torr; Temperature; Pressure; Pyrolysis;	A 50.3% B 28.9%

methane (34557-54-5) + Octafluorocyclobutane (115-25-3) → polytetrafluoroethylene (116-14-3) + perfluoropropylene (116-15-4) + Vinylidene fluoride (75-38-7) + 2,3,3,3-tetrafluoro-propene (754-12-1) + 1,1,2-trifluoroethylene (359-11-5)

Conditions	Yield
at 250 - 800℃; under 150.015 Torr; for 0.000175h; Temperature;	A 45.8% B 7.4% C 10.4% D 8.4% E 9.5%

perfluorocetane (355-49-7) → polytetrafluoroethylene (116-14-3) + perfluoropropylene (116-15-4) + Octafluorocyclobutane (115-25-3)

Conditions	Yield
at 195 - 550℃; under 75.7576 Torr; Temperature; Pressure; Pyrolysis;	A 36.1% B 42.7% C 6.1%

2-chloroundecafluoro-2-methyl-3-pentanone (83714-48-1) → perfluoropropylene (116-15-4) + perfluoropropanoyl fluoride (422-61-7) + perfluoro-2-methylpentan-3-one (756-13-8)

Conditions	Yield
With cesium fluoride In diethylene glycol dimethyl ether for 1h; Product distribution; Heating;	A n/a B n/a C 38%

heptafluoro-butyric acid iodoamide (377-51-5) → HFC-227ca (2252-84-8) + perfluoropropylene (116-15-4) + 1,1,2,2,3,3-Hexafluoro-cyclopropane (931-91-9)

Conditions	Yield
With sodium hydroxide byproducts: NH3; boiled in 30% NaOH for 5h;	A 38% B n/a C n/a
With NaOH byproducts: NH3; boiled in 30% NaOH for 5h;	A 38% B n/a C n/a

perfluorocetane (355-49-7) → polytetrafluoroethylene (116-14-3) + perfluoropropylene (116-15-4) + octafluoro-1-butene (357-26-6) + Octafluorocyclobutane (115-25-3)

Conditions	Yield
at 195 - 450℃; under 75.7576 Torr; Temperature; Pressure; Pyrolysis;	A 32.5% B 16.5% C 9.2% D 8.2%

perfluoroallylfluorosulphate (67641-28-5) → perfluoropropylene (116-15-4)

Conditions	Yield
With Trimethyl borate; sulfur trioxide at 25℃; for 168h;	30%
With cesium fluoride In 1,2-dimethoxyethane at 20℃;	25.5%

sodium cyanide (773837-37-9) + perfluoroallylfluorosulphate (67641-28-5) → fluorosulfonyl fluoride (640723-20-2, 2699-79-8, 12769-73-2) + perfluoropropylene (116-15-4) + methyl fluorosulfonate (558-25-8) + 2,2,3,4,4-pentafluorobut-3-ene nitrile (7792-66-7) + 2,3,3-trifluoroacryloyl fluoride (667-49-2) + sulfur dioxide (7446-09-5)

Conditions	Yield
In acetonitrile at -10 - 4.4℃; for 4.5h; Temperature; Inert atmosphere;	A n/a B n/a C n/a D 27% E n/a F n/a

perfluoroallylfluorosulphate (67641-28-5) + tetra-n-butylammonium cyanide (10442-39-4) → fluorosulfonyl fluoride (640723-20-2, 2699-79-8, 12769-73-2) + Carbonyl fluoride (353-50-4) + perfluoropropylene (116-15-4) + 2,2,3,4,4-pentafluorobut-3-ene nitrile (7792-66-7) + silicon tetrafluoride (7783-61-1)

Conditions	Yield
In dichloromethane at -20 - 20℃; for 4h; Solvent; Inert atmosphere;	A n/a B n/a C n/a D 22% E n/a

2-Chloro-F-propane (76-18-6) → perfluoropropylene (116-15-4)

Conditions	Yield
With hydrogen; NiCl2 on activated carbon at 250 - 300℃; for 0.00161111 - 0.00305556h;	21.6%

sodium cyanide (773837-37-9) + Triethylene glycol dimethyl ether (112-49-2) + perfluoroallylfluorosulphate (67641-28-5) → fluorosulfonyl fluoride (640723-20-2, 2699-79-8, 12769-73-2) + perfluoropropylene (116-15-4) + hydrogen cyanide (74-90-8) + Dimethyl ether (115-10-6) + ethanedinitrile (460-19-5) + methyl fluorosulfonate (558-25-8) + methyl-pentafluoroallyl ether (380-29-0) + 2,2,3,4,4-pentafluorobut-3-ene nitrile (7792-66-7) + 2,3,3-trifluoroacryloyl fluoride (667-49-2) + sulfur dioxide (7446-09-5) + fluorosulphonic acid (7789-21-1) + silicon tetrafluoride (7783-61-1)

Conditions	Yield
at -10 - 60℃; for 2.5h; Temperature; Inert atmosphere;	A n/a B n/a C n/a D n/a E n/a F n/a G n/a H 18% I n/a J n/a K n/a L n/a

...Expand

trifluoromethan (75-46-7) → polytetrafluoroethylene (116-14-3) + carbon tetrafluoride (75-73-0) + freon-218 (76-19-7) + perfluoropropylene (116-15-4) + Hexafluoroethane (76-16-4)

Conditions	Yield
With activated carbon supported potassium at 799.84℃; under 750.075 Torr; Pyrolysis; Inert atmosphere;	A 16.1% B n/a C n/a D 14.4% E n/a

heptafluorobutyric Acid (375-22-4) → perfluoropropylene (116-15-4)

Conditions	Yield
at 300℃; Reaktion des Natrium-Salzes;
at 235℃; Reaktion des Kalium-Salzes;
at 275℃; Reaktion des Barium-Salzes;

heptafluorobutyric Acid (375-22-4) → perfluoropropylene (116-15-4) + tetradecafluorohexane (355-42-0)

Conditions	Yield
at 300 - 320℃; Reaktion des Silber-Salzes.Pyrolysis;

heptafluorobutyric Acid (375-22-4) → perfluoropropylene (116-15-4) + perfluorobutyryl fluoride (335-42-2) + heptafluorobutyric anhydride (336-59-4)

Conditions	Yield
Pyrolyse von Lithium-, Calcium-, Strontium-, Blei- und Aluminium-Salz.Pyrolysis;

diethyl ether (60-29-7) + heptafluoro-propyl lithium (422-89-9) → perfluoropropylene (116-15-4)

Conditions	Yield
at 25℃;

1,2-dibromohexafluoropropane (661-95-0) → perfluoropropylene (116-15-4)

Conditions	Yield
With acetic acid; zinc at 25℃;
With ethanol; zinc

Chlorodifluoromethane (75-45-6) → perfluoropropylene (116-15-4)

Conditions	Yield
at 700℃; Pyrolysis;

polytetrafluoroethylene (116-14-3) → perfluoropropylene (116-15-4) + Hexafluoroethane (76-16-4) + perfluoroisobutylene (382-21-8) + Octafluorocyclobutane (115-25-3)

Conditions	Yield
at 600℃; Dimerisierung.Pyrolysis;
at 650℃; Dimerisierung.Pyrolysis;

polytetrafluoroethylene (116-14-3) → perfluoropropylene (116-15-4) + octafluoro-2-butene (360-89-4, 172368-67-1)

Conditions	Yield
at 700℃;
at 700℃;

1,2-dichlorohexafluoropropane (661-97-2) → perfluoropropylene (116-15-4)

Conditions	Yield
With ethanol; zinc at 40℃;
With ethanol; zinc at 100℃; unter Druck;

perfluoropropylene (116-15-4) + adamantane-1,3-dicarboxylic acid (39269-10-8) → 5-(1,1,2,3,3,3-Hexafluoro-propyl)-adamantane-1,3-dicarboxylic acid (86302-01-4)

Conditions	Yield
In acetic acid at 20℃; for 20h; Product distribution; Irradiation; var. time, var. temp., var. solvents, var. absorbed dose;	100%
In acetic acid at 70℃; for 20h; Irradiation;	100%

perfluoropropylene (116-15-4) + 1,2-diamino-benzene (95-54-5) → 2-(α-hydro-tetrafluoroethyl)benzimidazole (41185-74-4)

Conditions	Yield
With potassium fluoride In N,N-dimethyl-formamide	100%
With diethylamine In ethyl acetate at 7 - 12℃; for 1.25 - 2.5h;	85%
In ethyl acetate at 75℃; under 3000.3 - 9750.98 Torr; for 18h; Solvent; Autoclave;	75%

polytetrafluoroethylene (116-14-3) + perfluoropropylene (116-15-4) → copolymer; monomers: tetrafluoroethylene; hexafluoropropylene

Conditions	Yield
With ozone at -33.15 - 16.85℃;	100%

palladium(0)bis(tricyclohexylphosphine) (33309-88-5) + perfluoropropylene (116-15-4) → (η2-CF2=CFCF3)Pd(PCy3)2

Conditions	Yield
In toluene at 20℃; under 2660.18 Torr; for 0.5h; Inert atmosphere; Autoclave; regioselective reaction;	100%

perfluoropropylene (116-15-4) → 1,1,1,2,3,3-hexafluoropropane (431-63-0)

Conditions	Yield
With palladium/alumina; hydrogen at 59 - 121℃; under 1125.11 Torr; Pressure; Temperature;	99.9%
With hydrogen; Pd on alumina; corundum at 105 - 140℃; under 750.075 Torr; Product distribution / selectivity;	95.2%
With palladium Hydrogenation;

perfluoropropylene (116-15-4) + 2,2,3,3-tetrafluoropropanol (76-37-9) → 1,1,1,2,3,3-hexafluoro-3-(2,2,3,3-tetrafluoropropoxy)propane (65064-78-0)

Conditions	Yield
With potassium hydroxide In water at 50 - 60℃; under 3000.3 - 3750.38 Torr; Inert atmosphere; Autoclave;	99.8%
With potassium hydroxide at 20 - 40℃;	87%
With potassium hydroxide
With potassium hydroxide In acetonitrile cooling;

perfluoropropylene (116-15-4) → trifluoromethyl(perfluoroisopropyl)ketone (756-12-7) + CF(CF3)2-1,1,1,3,4,4,4-heptafluoro-3-trifluoromethylbutan-2-one

Conditions	Yield
With potassium fluoride; trifluoroacetic anhydride In diethylene glycol dimethyl ether	A 99.6% B n/a

perfluoropropylene (116-15-4) → 1,2-dibromohexafluoropropane (661-95-0)

Conditions	Yield
With bromine at 100℃; Cooling with acetone-dry ice;	99.41%
With bromine at 20℃; for 19h;	95%
With bromine for 19h;	95%

perfluoropropylene (116-15-4) + ethanol (64-17-5) → 1,1,2,3,3,3-hexafluoropropyl ethyl ether (380-34-7)

Conditions	Yield
With potassium hydroxide at 20 - 40℃;	99%
With potassium hydroxide
(i) NaN3, (ii) Br2, aq. NaBr, (iii) Hg; Multistep reaction;

porassium hydrogen difluoride (1256935-40-6) + perfluoropropylene (116-15-4) + Perfluoro pentanoyl fluoride (375-62-2) → CF(CF3)2-1,1,1,2,4,4,5,5,6,6,7,7,7-tridecafluoro-2-trifluoromethylheptan-3-one + 1,1,1,2,4,4,5,5,6,6,7,7,7-tridecafluoro-2-trifluoromethyl-heptan-3-one (87383-08-2)

Conditions	Yield
With potassium fluoride In diethylene glycol dimethyl ether	A n/a B 99%

perfluoropropylene (116-15-4) → 2,3,3,3-tetrafluoro-propene (754-12-1)

Conditions	Yield
Stage #1: perfluoropropylene With trimethylaminealane In benzene-d6 at 20℃; under 760.051 Torr; for 0.0833333h; Inert atmosphere; Schlenk technique; Stage #2: With trimethylaminealane In benzene-d6 at 40℃; for 72h; Inert atmosphere; Schlenk technique;	98.7%
With trimethylamin alane In benzene-d6 at 40℃; for 90h;	98%
With diisobutylaluminium hydride In diethylene glycol dimethyl ether at 20℃; for 19h;	94.5%
With palladium on activated charcoal; hydrogen at 120℃; Catalytic behavior; Reagent/catalyst;
With palladium on activated charcoal; hydrogen In neat (no solvent) at 120℃; under 750.075 Torr;

perfluoropropylene (116-15-4) → perfluoro-4-methyl-2-pentene (2070-70-4)

Conditions	Yield
With potassium fluoride; 18-crown-6 ether In acetonitrile at 130℃; under 11026.1 Torr; for 4h; Temperature; Reagent/catalyst; Pressure; Flow reactor; Industrial scale;	98.43%
cesium fluoride In acetonitrile at 0℃;	95%
With Tetrakis(dimethylamino)ethylen for 24h; Ambient temperature;	88%

perfluoropropylene (116-15-4) + perfluoropropanoyl fluoride (422-61-7) → perfluoro-2-methylpentan-3-one (756-13-8)

Conditions	Yield
With iron(III) trifluoride; 18-crown-6 ether In acetonitrile at 90℃; for 10h; Autoclave;	98.2%
With activated carbon BAU-A-2 supported 20 wtpercent CsF In neat (no solvent) at 95℃; under 1875.19 Torr;
at 160℃; under 750.075 Torr; for 10h; Gas phase;

methanol (67-56-1) + perfluoropropylene (116-15-4) → 1,1,1,2,3,3-hexafluoro-3-methoxypropane (382-34-3)

Conditions	Yield
With sodium for 1.5h;	98%
With 1,4-diaza-bicyclo[2.2.2]octane; dmap; DBN; 1,8-diazabicyclo[5.4.0]undec-7-ene In 1-methyl-pyrrolidin-2-one at 50℃; for 0.00277778h;	95.9%
With potassium hydroxide

Carbonyl fluoride (353-50-4) + perfluoropropylene (116-15-4) → perfluoroisobutyryl fluoride (677-84-9)

Conditions	Yield
cesium fluoride on NaF at 250℃; for 5h;	98%
cesium fluoride on NaF at 190℃;	95%
cesium fluoride on NaF at 190℃;	95%

perfluoropropylene (116-15-4) → C3F7IO3S

Conditions	Yield
With IOSO2F Ambient temperature;	98%

perfluoropropylene (116-15-4) + 5-Hydroxy-2-(4-nitrophenylazo)pyridine (35771-41-6) → [5-(1,1,2,3,3,3-Hexafluoro-propoxy)-pyridin-2-yl]-(4-nitro-phenyl)-diazene (110861-11-5)

Conditions	Yield
With potassium carbonate In acetonitrile at 22 - 36℃; for 0.5h;	98%

(N,N,N',N'-tetramethylethylenediamine)dimethylpalladium(II) + perfluoropropylene (116-15-4) + tris(1-methylethyl)phosphine (6476-36-4) → (η2-CF2=CFCF3)Pd(PiPr3)2

Conditions	Yield
In toluene at 20℃; under 2660.18 Torr; for 0.5h; Inert atmosphere; Autoclave; regioselective reaction;	98%

perfluoropropylene (116-15-4) + 1,3-bis(2,6-diisopropylphenyl)dihydroimidazol-2-ylidene (258278-28-3) → C30H38F6N2

Conditions	Yield
In tetrahydrofuran at 20℃; under 1277.21 Torr; Glovebox; Schlenk technique; Sealed tube;	98%

perfluoropropylene (116-15-4) + 1-ethoxy-1,3,3,3-tetrafluoro-2-trifluoromethyl-propene (360-58-7) → C7H5F9O

Conditions	Yield
at 50℃; for 5h;	98%

perfluoropropylene (116-15-4) → tetradecafluorohexane (355-42-0)

Conditions	Yield
With oxygen at 60℃; Temperature;	98%

perfluoropropylene (116-15-4) + ethene (74-85-1) → 1,1,2-trifluoro-2-(trifluoromethyl)cyclobutane (49852-57-5)

Conditions	Yield
With 4-tert-Butylcatechol at 320 - 350℃; for 5h; Inert atmosphere;	97.9%
at 250℃; for 18h;

perfluoropropylene (116-15-4) + 2,5-dichlorophenol (583-78-8) → 1,1,2,3,3,3-hexafluoropropoxy-2,5-dichlorobenzene (1026364-35-1)

Conditions	Yield
With sodium hydroxide In dimethyl sulfoxide at 25℃; under 2250.23 Torr; Solvent; Reagent/catalyst; Temperature; Pressure;	97.7%

methanol (67-56-1) + perfluoropropylene (116-15-4) → 1,1,2,3,3,3-hexafluoroisopropyl methyl ether (568550-25-4)

Conditions	Yield
With 1,3-bis-(diphenylphosphino)propane In acetonitrile at 80℃; under 1500.15 - 6000.6 Torr; for 20h; Reagent/catalyst; Solvent; Pressure; Temperature; Autoclave;	97.7%

perfluoropropylene (116-15-4) + trifluoroacetyl fluoride (354-34-7) → trifluoromethyl(perfluoroisopropyl)ketone (756-12-7)

Conditions	Yield
With 15-crown-5; cobalt(II) fuoride In acetonitrile at 80℃; for 10h; Reagent/catalyst; Autoclave;	97.5%
With liquid phase catalyst Cat15 at 60℃; for 3h; Reagent/catalyst; Autoclave; Inert atmosphere;	95.3%
With potassium fluoride In diethylene glycol dimethyl ether at 100 - 110℃; for 8h; Autoclave;	70%
potassium fluoride In N,N-dimethyl-formamide at 80℃; for 11.17h; Product distribution / selectivity;	54 - 84 %Chromat.
With activated carbon BAU-A-2 supported 20 wtpercent CsF In neat (no solvent) at 65 - 130℃; under 1875.19 Torr;

Carbonyl fluoride (353-50-4) + perfluoropropylene (116-15-4) → 1,1,1,2,4,5,5,5-octafluoro-2,4-bis(trifluoromethyl)pentan-3-one (813-44-5)

Conditions	Yield
With nickel(II) fluoride; 18-crown-6 ether In acetonitrile at 90℃; for 10h; Autoclave;	97.2%
With cesium fluoride In acetonitrile

perfluoropropylene (116-15-4) + 2,2,3,4,4,4-hexafluoro-1-butanol (382-31-0) → CF3CFHCF2CH2OCF2CFHCF3 (928617-03-2)

Conditions	Yield
Stage #1: perfluoropropylene; 2,2,3,4,4,4-hexafluoro-1-butanol With potassium carbonate In acetonitrile at 40℃; Stage #2: With potassium hydrogen difluoride; adogen 464 In diethylene glycol dimethyl ether at 110℃; for 24h;	97%

1-methyl-1H-imidazole (616-47-7) + perfluoropropylene (116-15-4) → 1-methyl-3-(1,1,2,3,3,3-hexafluoropropyl)imidazolium chloride

Conditions	Yield
With hydrogenchloride In diethyl ether; acetonitrile at 20℃; under 3863.02 Torr;	97%

perfluoropropylene (116-15-4) + 4-isopropenylphenol (4286-23-1) → p-(perfluorononenyloxy)isopropenylbenzene

Conditions	Yield
Stage #1: perfluoropropylene; 4-isopropenylphenol With triethylamine at 40℃; for 3h; Stage #2: With calcium carbonate at 40℃; for 2h;	96.7%

Upstream product

• 75-45-6 Chlorodifluoromethane 
• 661-97-2 1,2-dichlorohexafluoropropane 
• 754-34-7 1,1,1,2,2,3,3-heptafluoro-3-iodo-propane 
• 378-90-5 perfluoro-4-heptanone 
• 917-54-4 methyllithium 
• 124-38-9 carbon dioxide 
• 139-02-6 sodium phenoxide 
• 431-53-8 1,2-dichlorotetrafluoropropene 
• 14003-57-7 trans-1-chloro-1,2,3,3,3-pentafluoro-1-propene 
• 422-55-9 1-chloro-1,1,2,2,3,3-hexafluoropropane 
• 379-16-8 perfluoro(methylcyclopropane) 
• 14003-62-4 cis-1-chloro-1,2,3,3,3-pentafluoro-1-propene 
• 360-89-4 octafluoro-2-butene 
• 375-22-4 heptafluorobutyric Acid 

Downstream Products

• 382-31-0 2,2,3,4,4,4-hexafluoro-1-butanol 
• 382-34-3 1,1,1,2,3,3-hexafluoro-3-methoxypropane 
• 384-90-7 1,3,3,3-tetrafluoro-1,2-diphenyl-propene 
• 41424-74-2 trans-1-(5-Brom-2-methoxyphenyl)-pentafluorpropen 
• 41424-33-3 p-MeOC₆H₄(CF=CFCF₃) 
• 41424-73-1 trans-1-p-(Methoxyphenyl)-pentafluorpropen 
• 813-44-5 1,1,1,2,4,5,5,5-octafluoro-2,4-bis(trifluoromethyl)pentan-3-one 
• 13528-79-5 2,2,3,4,4,4-hexafluorobutylbenzene 
• 55012-43-6 2,3,3-trifluoro-2-trifluoromethylpropylbenzene 
• 94412-88-1 2-(1,1,2,3,3,3-hexafluoropropyl)-1,4-dioxane 
• 359-58-0 1-chloro-1,1,2,3,3,3-hexafluoro-propane 
• 51346-64-6 CF₃CClFCHF₂ 
• 58705-93-4 2,2,3,4,4,4-hexafluorobutyl methyl ether 
• 431-89-0 1,1,1,2,3,3,3-Heptafluoropropane 

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Labelling of the CFC-alternative, 2H-heptafluoropropane (HFC 227ea), with fluorine-18

Various reactions of no-carrier-added K(+)-aminopolyether 2.2.2-fluoride were examined for labelling the CFC-alternative, 2H-heptafluoropropane (HFC 227ea), with the positron-emitting radioisotope, fluorine-18 (t1/2 = 109.7 min).Reaction with 2H-hexafluoroisopropyl tosylate incorporated less than 2percent of the radioactivity into HFC 227ea and about 12percent into three other volatile products.Reaction with hexafluoropropene led to a high incorporation of fluorine-18 (80percent) into four radioactive products, namely the desired HFC 227ea, hexafluoropropene, perfluoro-isohex-2-ene and an unknown, in a molar ratio of 5:4:38:3, respectively.Although reaction with 1-iodo-2H-hexafluoropropane gave HFC 227ea in a much higher radiochemical yield (50percent decay-corrected), the best radiochemical yield (80percent decay-corrected) was obtained by exchange with HFC 227ea.The mechanistic bases of the results are discussed.An efficient fully shielded and automated procedure was devised for labelling HFC 227ea with fluorine-18 in high radioactivity, based on the successful exchange reaction and GC purification. HFC 227ea was obtained in high radiochemical purity (>99percent) and high chemical purity (>98.4percent) at 80 min from the start of radiosynthesis.This product is suitable for studies of the disposition of HFC 227ea in vivo. - Keywords: 2H-Heptafluoropropane; HFC 227ea; Fluorine-18; Exchange labelling; Mass spectrometry; Reaction mechanisms

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Perfluoroalkyl Grignard Reagents: NMR Study of 1-Heptafluoropropylmagnesium Chloride in Solution

We report on the generation of a perfluoroalkyl Grignard reagent (FRMgX) by exchange reaction between a perfluoroalkyl iodide (FR-I) and a Grignard reagent (RMgX). 19F NMR was applied to monitor the generation of n-C3F7MgCl. Additional NMR techniques, including 19F COSY, NOESY, and pulsed gradient spin-echo (PGSE) diffusion NMR, were invoked to assign peaks observed in 19F spectrum. Schlenk equilibrium was observed and was significantly influenced by solvent, diethyl ether, or THF.

Preparation of trifluoroiodomethane via vapor-phase catalytic reaction between hexafluoropropylene oxide and iodine

Based on our previous investigation on the reaction mechanism to produce difluorocarbene and subsequent CF3I starting with CHF3 and I2, a new route for preparing CF3I at a relative low temperature, 200 °C, has b

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A novel and efficient synthetic route to perfluoroisobutyronitrile from perfluoroisobutyryl acid

A novel synthetic route to perfluoroisobutyronitrile from perfluoroisobutyryl acid which has mild conditions and low toxicity is described. This study introduces detailed synthetic protocols and characterization including GC-MS, 13C NMR and 19F NMR spectroscopy of perfluoroisobutyryl acid, perfluoroisobutyryl chloride, perfluoroisobutyl amide and perfluoroisobutyronitrile. Besides, this route is superior to the established patent and shows potential application in high voltage electrical equipment.

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Novel synthetic route to perfluoroallyl cyanide (PFACN) reacting perfluoroallyl fluorosulfonate with cyanide

A novel synthetic method for the preparation of perfluoroallyl cyanide CF2[dbnd]CFCF2CN (PFACN) is presented. This includes the addition – elimination reaction of cyanide anion with perfluoroallyl fluorosulfate CF2[dbnd]CF