23976-42-3

Upstream product

• 2415-85-2 3-oxo-N-(p-tolyl)butanamide 
• 106-49-0 p-toluidine 

Downstream Products

• 117534-54-0 3-Oxo-4-thiocyanato-N-p-tolyl-butyramide 
• 96286-58-7 2-Benzoylamino-4-oxo-4,5-dihydro-thiophene-3-carboxylic acid p-tolylamide 
• 138990-72-4 3-Oxo-2-[3-phenyl-4-(p-tolylcarbamoyl-methyl)-3H-thiazol-(2Z)-ylidene]-butyric acid ethyl ester 
• 96286-63-4 N-(4-methylphenyl)-4,5-dihydro-4-oxo-2-(phenylamino)-3-furancarboxamide 
• 115320-94-0 4-Oxo-2-p-tolylamino-4,5-dihydro-furan-3-carboxylic acid phenylamide 
• 138990-68-8 Cyano-[3-phenyl-4-(p-tolylcarbamoyl-methyl)-3H-thiazol-(2Z)-ylidene]-acetic acid ethyl ester 
• 138990-70-2 2-[2-(1-Acetyl-2-oxo-propylidene)-3-phenyl-2,3-dihydro-thiazol-4-yl]-N-p-tolyl-acetamide 
• 138990-66-6 2-(2-Dicyanomethylene-3-phenyl-2,3-dihydro-thiazol-4-yl)-N-p-tolyl-acetamide 
• 97226-70-5 2-Ethoxy-4-oxo-4,5-dihydro-1H-pyrrole-3-carboxylic acid p-tolylamide 
• 85322-34-5 (Z)-5-(p-methylphenylcarbamoyl)-methylene-3-phenyl-5,6-dihydro-4H-1,2,4-oxadiazine 
• 117534-66-4 3-Oxo-4-phenylazo-4-thiocyanato-N-p-tolyl-butyramide 
• 117534-56-2 2-(2-Dicyanomethyl-thiazol-4-yl)-N-p-tolyl-acetamide 

Relevant academic research and scientific papers

Visible Light-Induced Pericyclic Cascade Reaction for the Synthesis of Quinolinone Derivatives with an Oxabicyclo[4.2.0]octene Skeleton

A photoinduced pericyclic cascade reaction has been developed to afford oxabicyclo[4.2.0]octenes. Mechanistic studies show that this reaction undergoes [2 + 2]-photocycloaddition, base-promoted elimination, retro-4π-electrocyclization, [1,5]-H shift, and

Drug-induced modifications of the immune response. 12. 4,5-Dihydro-4-oxo-2-(substituted amino)-3-furancarboxylic acids and derivatives as novel antiallergic agents

The synthesis of a series of novel 4,5-dihydro-4-oxo-2-(substituted amino)-3-furancarboxylic acids, salts, esters, and amides is described. The title compounds when tested in the mediator-induced dermal vascular permeability and active anaphylaxis assays in rats demonstrated moderate to potent antiallergic activity. The [2-trans-(4-methyl-phenyl)cyclopropyl]amino analogue 53 emerged as the most active derivative. Thus, when administered intraperitoneally to rate at a dose of 100 mg/kg, it inhibited the action of the mediators serotonin, histamine, and bradykinin by 100%. In the active anaphylaxis assay in rats, compound 30 suppressed the edema by 81% at a dose of 100 mg/kg, following intraperitoneal administration.