96286-63-4Relevant academic research and scientific papers
The use of anilinodihydrofurans in the synthesis of novel heterocyclic compounds
Hammouda,Zeid, Z. M. Abou,Etman,Metwally
experimental part, p. 17 - 21 (2012/01/06)
Alkyl 4-oxo-2-phenylamino-4,5-dihydrofuran-3-carboxylates were used for the preparation of alkyl 5-amino-7-aryl-2-{[aryl(hydroxy)methyl](phenyl)amino}-4,6- dicyano-1-benzofuran-3-carboxylates, 4-oxo-2-phenylamino-N-(p-tolyl)-4,5- dihydrofuran-3-carboxamid
Drug-induced modifications of the immune response. 12. 4,5-Dihydro-4-oxo-2-(substituted amino)-3-furancarboxylic acids and derivatives as novel antiallergic agents
Mck,Zazulak,Radov,baer,Steward,Elzer,Kinsolving,Georgiev
, p. 1910 - 1918 (2007/10/02)
The synthesis of a series of novel 4,5-dihydro-4-oxo-2-(substituted amino)-3-furancarboxylic acids, salts, esters, and amides is described. The title compounds when tested in the mediator-induced dermal vascular permeability and active anaphylaxis assays in rats demonstrated moderate to potent antiallergic activity. The [2-trans-(4-methyl-phenyl)cyclopropyl]amino analogue 53 emerged as the most active derivative. Thus, when administered intraperitoneally to rate at a dose of 100 mg/kg, it inhibited the action of the mediators serotonin, histamine, and bradykinin by 100%. In the active anaphylaxis assay in rats, compound 30 suppressed the edema by 81% at a dose of 100 mg/kg, following intraperitoneal administration.
A Novel Synthesis of Heterocyclic β-Enaminoamides: The Reaction of Halomethyl Acet-p-toluidide with Isothiocyanates and with Isocyanates
Ibrahim, Nadia Sobhy,Sadek, Kamal Usef,Aziz, Suzan Ibrahim,Elnagdi, Mohamed Hilmy
, p. 129 - 131 (2007/10/02)
A novel synthesis of thiophene and furan β-enaminoamides via the reaction of halomethyl acet-p-toluidide with isothiocyanates and isocyanates were reported. - Keywords: Bromomethyl Acet-p-toluidide, Isocyanate, Isothiocyanates, Enaminothiophene, Enaminofu
