239784-37-3

Upstream product

• 30725-00-9 2,3-O-isopropylidene-D-ribonic-γ-lactone 
• 239784-34-0 (S)-2-{[(4R,5R)-5-((S)-1-Hydroxy-2-iodo-ethyl)-2,2-dimethyl-[1,3]dioxolane-4-carbonyl]-amino}-4-methyl-pentanoic acid tert-butyl ester 
• 239784-33-9 (S)-2-{[(4R,5R)-5-((S)-2-Bromo-1-hydroxy-ethyl)-2,2-dimethyl-[1,3]dioxolane-4-carbonyl]-amino}-4-methyl-pentanoic acid tert-butyl ester 
• 239784-30-6 (S)-2-((3aR,7R,7aR)-7-Hydroxy-2,2-dimethyl-4-oxo-tetrahydro-[1,3]dioxolo[4,5-c]pyridin-5-yl)-4-methyl-pentanoic acid tert-butyl ester 
• 239784-35-1 (S)-2-[((4R,5R)-2,2-Dimethyl-5-(R)-oxiranyl-[1,3]dioxolane-4-carbonyl)-amino]-4-methyl-pentanoic acid tert-butyl ester 
• 239784-31-7 (S)-2-[((3aR,4R,6aR)-2,2-Dimethyl-6-oxo-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl)-amino]-4-methyl-pentanoic acid tert-butyl ester 
• 220792-02-9 2,3-O-isopropylidene-5-O-trifluoromethanesulfonyl-D-ribono-1,4-lactone 
• 94324-23-9 5-bromo-5-deoxy-2,3-O-isopropylidene-D-ribono-1,4-lactone 
• 96239-82-6 2,3-O-isopropylidene-5-iodo-D-ribono-1,4-lactone 
• 239784-36-2 (S)-2-((3aR,7R,7aR)-7-Benzyloxy-2,2-dimethyl-4-oxo-tetrahydro-[1,3]dioxolo[4,5-c]pyridin-5-yl)-4-methyl-pentanoic acid tert-butyl ester 

Downstream Products

• 239784-38-4 (3S,4S,5R)-3-azido-5-benzyloxy-N-[(1S)-1-(tert-butoxycarbonyl)-3-methylbutyl]-4-hydroxypiperidin-2-one 
• 239784-28-2 (3S,4S,5R)-3-amino-5-benzyloxy-N-[(1S)-1-(tert-butoxycarbonyl)-3-methylbutyl]-4-hydroxypiperidin-2-one 

Relevant academic research and scientific papers

3-amino-2-piperidones as constrained pseudopeptides: Preparation of a new Ser-Leu surrogate

We describe a stereoselective preparation of 3-amino-2-piperidone 1, a new conformationally constrained Ser-Leu surrogate. The key steps of the synthesis of compound I are the lactamisation of the secondary aminolactone 4 and the amination of the 3-position via the sulfite 2.