Tetrahedron Letters p. 4865 - 4868 (1999)
Update date:2022-09-26
Topics:
Piro, Jordi
Rubiralta, Mario
Giralt, Ernest
Diez, Anna
We describe a stereoselective preparation of 3-amino-2-piperidone 1, a new conformationally constrained Ser-Leu surrogate. The key steps of the synthesis of compound I are the lactamisation of the secondary aminolactone 4 and the amination of the 3-position via the sulfite 2.
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