239807-71-7

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 198755-87-2 (2S)-1-chloro-3-[(phenylmethyl)amino]-2-propanol 
• 100-46-9 benzylamine 

Downstream Products

• 239807-72-8 [(2R)-2-hydroxy-3-[4-[2-(1-methylethoxy)phenyl]-1-piperazinyl]propyl]-(phenylmethyl)carbamic acid, 1,1-dimethylethyl ester 
• 239807-73-9 (S)-1-Benzylamino-3-[4-(2-isopropoxy-phenyl)-piperazin-1-yl]-propan-2-ol 

Relevant academic research and scientific papers

An improved synthesis of enantiomerically pure RWJ 69442, a development candidate for the treatment of benign prostatic hyperplasia

This report describes an improved synthesis of enantiomerically pure (S)-2-[4-(Dimethylamino)phenyl]- 2,3-dihydro-N-[2-hydroxy-3-[4-[2-(1-methylethoxy)-phenyl]-1-piperazinyl] propyl]-1,3-dioxo-1H- isoindole-5-carboxamide (RWJ 69442), a potent and selectiv