198755-87-2

Upstream product

• 67843-74-7 (S)-epichlorohydrin 
• 100-46-9 benzylamine 
• 224323-52-8 (S)(E,Z)-1-(benzylideneamino)-3-chloropropan-2-ol 
• 100-52-7 benzaldehyde 

Downstream Products

• 239807-71-7 ((2S)-3-chloro-2-hydroxypropyl)(phenylmethyl)carbamic acid, 1,1-dimethylethyl ester 
• 1429333-88-9 N-[(2S)-3-chloro-2-(acetyloxy)propyl]-N-benzyl-5-chlorothiophene-2-carboxamide 
• 1429333-90-3 5-chloro-N-[{(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl]-N-benzyl-2-thiophene carboxamide 
• 1429333-91-4 N-[(2S)-3-chloro-2-{(phenyloxycarbonyl)oxy}propyl]-N-benzyl-5-chlorothiophene-2-carboxamide 
• 1429333-92-5 N-(S)-(1-oxiranylmethyl)-N-benzyl-5-chlorothiophene-2-carboxamide 
• 1429333-93-6 N-[(R)-2-hydroxy-3-{ 4-(3-oxomorpholin-4-yl)phenylamino}propyl]-N-benzyl-5-chlorothiophene-2-carboxamide 
• 1093752-88-5 (5R)-5-(aminomethyl)-3-benzyl-1,3-oxazolidin-2-one 
• 1093752-87-4 (5S)-5-(azidomethyl)-3-benzyl-1,3-oxazolidin-2-one 
• 239807-72-8 [(2R)-2-hydroxy-3-[4-[2-(1-methylethoxy)phenyl]-1-piperazinyl]propyl]-(phenylmethyl)carbamic acid, 1,1-dimethylethyl ester 
• 239807-73-9 (S)-1-Benzylamino-3-[4-(2-isopropoxy-phenyl)-piperazin-1-yl]-propan-2-ol 

Relevant academic research and scientific papers

PROCESSES FOR THE PREPARATION OF 5-CHLORO-N-({(5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL) PHENYL]-1,3-OXAZOLIDIN-5-YL}METHYL)-2-THIOPHENE-CARBOXAMIDE AND INTERMEDIATES THEREOF

TThe present invention provides processes for the preparation of 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophene-carboxamide (I) and intermediates thereof. Also provides novel intermediates and their use in the synthesis of oxazolidine derivatives.

CETP INHIBITORS DERIVED FROM BENZOXAZOLE ARYLAMIDES

Compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, are potent CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. In formula I, A-B is an arylamide moiety.

An improved synthesis of enantiomerically pure RWJ 69442, a development candidate for the treatment of benign prostatic hyperplasia

This report describes an improved synthesis of enantiomerically pure (S)-2-[4-(Dimethylamino)phenyl]- 2,3-dihydro-N-[2-hydroxy-3-[4-[2-(1-methylethoxy)-phenyl]-1-piperazinyl] propyl]-1,3-dioxo-1H- isoindole-5-carboxamide (RWJ 69442), a potent and selectiv