23982-76-5

Usage

Class

Heterocyclic compound

Subclass

Benzimidazoisoquinolinone derivatives

Structural feature

Chlorine atom attached to the benzene ring

Unique feature

Fused ring structure

Application

Building block in the synthesis of pharmaceuticals and agrochemicals

Biological activities

Diverse, including potential antitumor, antiviral, and anti-inflammatory properties

Importance

Target for drug discovery and development due to its potential therapeutic properties

Upstream product

• 81-84-5 1,8-Naphthalic anhydride 
• 95-83-0 4-Chloro-1,2-phenylenediamine 
• 132180-93-9 2-(5-chloro-2-nitro-phenyl)-benz[de]isoquinoline-1,3-dione 
• 89-63-4 4-Chloro-2-nitroaniline 
• 1635-61-6 5-chloro-2-nitroaniline 

Downstream Products

• 88777-48-4 Toluene-4-sulfonate10-chloro-13-methyl-7-oxo-7H-benzo[de]benzo[4,5]imidazo[2,1-a]isoquinolin-13-ium; 

Relevant academic research and scientific papers

ARYL HYDROCARBON RECEPTOR ACTIVATORS

Small molecule AhR ligands are disclosed. The ligands can induce the differentiation of Tr1 cells to suppress pathogenic immune responses without inducing nonspecific immune suppression. Methods of treatment of autoimmune diseases using the AhR ligands are also disclosed.

The Identification of 10 and 11 Substituted 7H-Benzimidazobenzisoquinolin-7-ones through 1N NOE Studies on their Methyl p-Toluenesulfonate Salts

The spectral similarities of 10 and 11 substituted 7H-benzimidazobenzisoquinolin-7-ones hinder the identification of the individual isomers.Preparation of the 13-methyl p-toluenesulfonate salts of these compounds has allowed the assignment by the use of NOE techniques.Saturation of the N-methyl caused an NOE at H-12.The coupling pattern of H-12 then provides identification of the compound.

Preparation of isoquinoline derivatives useful as immune regulants

This invention provides for a process of preparing certain trifluoromethyl substituted 7H-benzimidazo[2,1-a]benz[de]isoquinoline-7-ones.