23995-88-2Relevant articles and documents
2-amino-4-substituted pyridine derivative as well as synthesis method and application thereof
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, (2019/08/06)
The invention discloses a 2-amino-4-substituted pyridine derivative as well as a synthesis method and an application thereof. The derivative with the structural formula is a compound with the structure or pharmacologically acceptable salt, hydrate, solvate, polymorphic substance, tautomer, stereoisomer, isotope derivative or prodrug of the compound. The 2-amino-4-substituted pyridine derivative has higher EGFR (epidermal growth factor receptor) inhibition activity, has higher inhibition activity for human epidermal cell carcinoma cells, glioblastoma cells and the like and can be used for preparing drugs for treating and/or preventing and/or delaying and/or assisting in treatment and/or treatment of diseases related with too high EGFR activity.