23995-88-2

Usage

Uses

Used in Pharmaceutical Industry:
1-(1-Methyl-4-piperidinyl)piperazine is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure allows it to be a key component in the development of new drugs with specific therapeutic properties.
Used in Chemical Industry:
1-(1-Methyl-4-piperidinyl)piperazine is used as a building block for the preparation of complex organic molecules, particularly in the synthesis of Pyrazolo Estratrienes. These compounds serve as inhibitors of 17-HSD1, an enzyme involved in the synthesis of sex hormones. By targeting this enzyme, Pyrazolo Estratrienes have potential applications in the treatment of hormone-related disorders and cancers.

InChI:InChI=1/C10H21N3/c1-12-6-2-10(3-7-12)13-8-4-11-5-9-13/h10-11H,2-9H2,1H3

Upstream product

• 1445-73-4 1-Methyl-4-piperidone 
• 2759-28-6 1-phenylmethylpiperazine 

Downstream Products

• 1017275-66-9 {4-[4-(1-methyl-piperidin-4-yl)-piperazin-1-yl]-phenyl}-acetonitrile 
• 873955-76-1 4-(1-methyl-piperidin-4-yl)-piperazine-1-carboxylic acid [5-methoxy-2-oxo-3-(2-propoxy-phenyl)-2,3-dihydro-1H-indol-3-yl]-ester 
• 1037238-62-2 N-[5-cyano-1-[(2,4-dimethoxyphenyl)sulphonyl]-3-(2-ethoxypyridin-3-yl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-(1-methylpiperidin-4-yl)piperazine-1-carboxamide 
• 1072342-54-1 {1-[(4-methoxy-2,6-dimethylphenyl)sulfonyl]piperidin-2-yl}methyl 4-(1-methylpiperidin-4-yl)piperazine-1-carboxylate 
• 1076863-48-3 C₂₅H₃₁N₅O 
• 1076863-54-1 C₂₉H₄₀N₆O 

Relevant academic research and scientific papers

2-amino-4-substituted pyridine derivative as well as synthesis method and application thereof

The invention discloses a 2-amino-4-substituted pyridine derivative as well as a synthesis method and an application thereof. The derivative with the structural formula is a compound with the structure or pharmacologically acceptable salt, hydrate, solvate, polymorphic substance, tautomer, stereoisomer, isotope derivative or prodrug of the compound. The 2-amino-4-substituted pyridine derivative has higher EGFR (epidermal growth factor receptor) inhibition activity, has higher inhibition activity for human epidermal cell carcinoma cells, glioblastoma cells and the like and can be used for preparing drugs for treating and/or preventing and/or delaying and/or assisting in treatment and/or treatment of diseases related with too high EGFR activity.

Piperazine derivatives, medicaments comprising these compounds, their use and processes for their preparation

The present invention relates to piperazine derivatives of the general formula STR1 in which Ra, Y1 to Y3 and E are defined herein, tautomers thereof, stereoisomers thereof, including their mixtures, and salts thereof, and in particular physiologically tolerated salts thereof with inorganic or organic acids or bases. These compounds have valuable pharmacological properties, such as aggregation-inhibiting activity. This invention also relates to medicaments comprising these compounds and to processes for the preparation of these compounds.