24004-48-6Relevant academic research and scientific papers
Synthesis of Indolizines through Oxidative Linkage of C-C and C-N Bonds from 2-Pyridylacetates
Chandra Mohan, Darapaneni,Ravi, Chitrakar,Pappula, Venkatanarayana,Adimurthy, Subbarayappa
, p. 6846 - 6855 (2015/10/06)
Synthesis of indolizine-1-carboxylates through the Ortoleva-King reaction of 2-pyridylacetate followed by the Aldol condensation under mild reaction conditions has been described. This protocol is compatible with a broad range of functional groups, and it has been also successfully extended to unsaturated ketones, bringing about the regioselective formation of benzoyl-substituted indolizines through Michael addition followed by C-N bond formation, which are difficult to prepare by previous methods in a single step.
Synthesis of functionalized indolizines via copper-catalyzed annulation of 2-alkylazaarenes with α,β-unsaturated carboxylic acids
Yang, Yuzhu,Xie, Chunsong,Xie, Yongju,Zhang, Yuhong
supporting information; experimental part, p. 957 - 959 (2012/04/04)
A novel copper-catalyzed annulation of 2-alkylazaarenes with α,β-unsaturated carboxylic acids has been accomplished. This reaction featuring C-H olefination and decarboxylative amination processes provides a concise access to C-2 arylated indolizines from simple and readily available starting materials.
Synthesis of indolizine derivatives with selective antibacterial activity against Mycobacterium tuberculosis
Gundersen, Lise-Lotte,Charnock, Colin,Negussie, Ayele Hailu,Rise, Frode,Teklu, Solomon
, p. 26 - 35 (2007/10/03)
1-Substituted indolizines with activity against Mycobacterium tuberculosis have been synthesized. The most active compounds carry an hydroxyphenylmethyl- or hydroxyalkyl substituent in the indolizine 1-position. The alkyl chain should be moderately long (C-5 or C-6). Aryl groups in the 2- and 3-position of the indolizine are also required. Removal of the 3-substituent resulted in significant loss of activity. A nitrile substituent in the 7-position is beneficial for both chemical stability and bioactivity. The compounds studied display a narrow antibacterial spectrum and appear to be quite selective antimycobacterial compounds. Moderate activity against certain pathogenic protozoa was also observed.
