2401-22-1

Usage

Chemical Class

Aromatic compounds

Type of Compound

Halogenated derivative of methylbenzene

Molecular Structure

Contains a chlorine atom and an iodine atom

Uses

Intermediate in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds; used in research and development laboratories as a reagent in organic chemistry reactions

Safety Precautions

Proper handling and safety precautions should be followed when working with this substance.

InChI:InChI=1/C7H6ClI/c1-5-2-3-6(8)7(9)4-5/h2-4H,1H3

Upstream product

• 106-43-4 para-chlorotoluene 
• 202982-72-7 4-chloro-3-iodophenol 
• 74-88-4 methyl iodide 
• 625-95-6 3-Iodotoluene 
• 29289-13-2 2-iodo-4-methylaniline 
• 95-81-8 2-chloro-5-methylaniline 

Downstream Products

• 861782-71-0 2-(2-chloro-5-methyl-phenylsulfanyl)-benzoic acid 
• 887623-21-4 1,2-dideoxy-1-(2-chloro-5-methylphenyl)-β-D-ribofuranose 
• 19482-24-7 2-chloro-5-methyl-1,1'-biphenyl 
• 21991-42-4 6-methyl-1,2,3,4-tetraphenylnaphthalene 

Relevant academic research and scientific papers

ARYLMETHYLENE HETEROCYCLIC COMPOUNDS AS KV1.3 POTASSIUM SHAKER CHANNEL BLOCKERS

A compound of Formula (I) or a pharmaceutically acceptable salt thereof is described, wherein the substituents are as defined herein. Pharmaceutical compositions comprising the same and method of using the same are also described.

The chlorinated aromatic iodine compound method

PROBLEM TO BE SOLVED: To provide an industrially advantageous production method that makes it possible to produce aromatic chloroiodine compounds.SOLUTION: A production method of an aromatic chloroiodine compound is characterized by making an aromatic iodine compound and a sulfuryl chloride react with each other in the presence of a specific Lewis acid catalyst and a sulfur compound.

METHOD OF PRODUCING IODIZING AGENT, AND METHOD OF PRODUCING AROMATIC IODINE COMPOUND

A method of the present invention, for producing an iodizing agent, includes the step of electrolyzing iodine molecules in a solution by using an acid as a supporting electrolyte. This realizes (i) a method of producing an iodine cation suitable for use as an iodizing agent that does not require a sophisticated separation operation after iodizing reaction is completed, and (ii) an electrolyte used in the method. Further, a method of the present invention, for producing an aromatic iodine compound, includes the step of causing an iodizing agent, and an aromatic compound whose nucleus has one or more substituent groups and two or more hydrogen atoms, to react with each other under the presence of a certain ether compound. This realizes such a method of producing an aromatic iodine compound that position selectivity in iodizing reaction of an aromatic compound is improved.

Remarkable sensitivity to DNA base shape in the DNA polymerase active site

(Figure Presented) Shaping up: DNA polymerase I can distinguish easily and with high sensitivity between nucleobases that have the same size but differ in shape. The shape, altered through variation in the position of the halogen substituent(s), plays mor

Dehalogenation of o-dihalogen substituted arenes and α,α′-dihalogen substituted o-xylenes with lanthanum metal

It was found that lanthanum metal caused the dehalogenation of o-dihalogen substituted arenes and α,α′-dihalogen substituted o-xylenes to generate the corresponding benzynes and o-quinodimethanes. When o-dihalogen substituted arenes were allowed to react with lanthanum metal in the presence of dienes, the Diels-Alder products between benzyne and dienes were formed in moderate to good yields. Similarly, the Diels-Alder adducts of o-quinodimethane with dienophiles were obtained, in the reaction of α,α′-dibromo-o-xylenes with lanthanum metal in the presence of dienophiles.

STOICHIOMETRIC AND CATALYTIC OXIDATIVE IODINATION OF AROMATIC COMPOUNDS IN THE PRESENCE OF NITROGEN-CONTAINING OXIDIZING AGENTS IN AQUEOUS TRIFLUOROACETIC ACID

The conditions for oxidative monoiodination of benzene, halogenobenzenes, toluene, halogenotoluenes, and p-toluic acid in solvents based on trifluoroacetic acid were studied.Yields of the respective iodoarenes close to quantitative were obtained in systems containing 10-20 vol. percent of water in the solvent with equimolar amounts of alkali-metal metal iodides in relation to the substrate in the presence of stoichiometric (under anaerobic conditions) or catalytic (in the presence of oxygen or air) amounts of alkali-metal nitrates.The analogous reactions with nitrites can only be conducted under aerobic conditions.These iodinating systems are compared with systems based on acetic acid containing iodine and mixtures of sulfuric and nitric acids.The conditions for the iodination of toluene and for the transformations of the obtained iodotoluenes in the presence of nitrogen-containing oxidizing agents in trifluoroacetic acid solutions were studied in detail.It was shown that p-iodotoluene undergoes ipso-nitrodeiodination to a significant degree under these conditions.It is supposed that the iodinating agent in the investigated systems is trifluoroacetyl hypoiodite.Data on the assignment of the PMR spectra of the synthesized isomeric nitroiodotoluenes and chloroiodotoluenes by a simple additive method are given.