240135-89-1Relevant academic research and scientific papers
Peptidyl prolyl isomerase Pin1-inhibitory activity of d-glutamic and d-aspartic acid derivatives bearing a cyclic aliphatic amine moiety
Nakagawa, Hidehiko,Seike, Suguru,Sugimoto, Masatoshi,Ieda, Naoya,Kawaguchi, Mitsuyasu,Suzuki, Takayoshi,Miyata, Naoki
, p. 5619 - 5624 (2015)
Pin1 is a peptidyl prolyl isomerase that specifically catalyzes cis-trans isomerization of phosphorylated Thr/Ser-Pro peptide bonds in substrate proteins and peptides. Pin1 is involved in many important cellular processes, including cancer progression, so
Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases
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, (2008/06/13)
Compounds of formula (I) wherein W is —OH or —NHOH; X is an optionally substituted heterocycle, NR1SO2R2, heterocyclylalkythio, CONR2R3or NR1COR2; Y, Z, R1-R3and n are as defined in the application. Compounds (I) are inhibitors of matrix-degrading metalloproteinases and are use for the treatment of related conditions.
Sulfonylamino acid and sulfonylamino hydroxamic acid derivatives
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, (2008/06/13)
Compounds of formula wherein W is —OH or —NHOH; X is a heterocycle with the proviso that when X is a nitrogen containing heterocycle, the heterocycle is attached to the (CH2)mmoiety by a ring nitrogen, —CONR2R3,
