24014-19-5

Usage

InChI:InChI=1/C6H7NO/c1-5-2-6(4-8)7-3-5/h2-4,7H,1H3

Upstream product

• 616-43-3 3-methylpyrrole 
• 74-90-8 hydrogen cyanide 
• 68-12-2 N,N-dimethyl-formamide 
• 134209-74-8 5-Formyl-3-methyl-1H-pyrrol-2-carbonsaeure 
• 2199-44-2 3,5-dimethyl-2-ethoxycarbonyl-1H-pyrrole 
• 123-54-6 acetylacetone 
• 40236-19-9 benzyl 3,5-dimethylpyrrole-2-carboxylate 
• 94781-44-9 5-Formyl-3-methyl-1H-pyrrol-2-carbonsaeure-benzylester 

Downstream Products

• 179928-11-1 6-methyl-3-[(4-methylphenyl)sulfonyl]pyrrolo[1,2-c]pyrimidine 
• 187842-18-8 1-Benzenesulfonyl-4-methyl-1H-pyrrole-2-carbaldehyde 

Relevant academic research and scientific papers

PYRROLOTRIAZINONES AND IMIDAZOTRIAZINONES AS UBIQUITIN-SPECIFIC PROTEASE 7 INHIBITORS

The invention relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where R1, R2, R3, R4, R5, R5′, R6, X1, X2, m, and n are described herein.

Synthesis of 2,2′-bipyrrole-5-carboxaldehydes and their application in the synthesis of B-ring functionalized prodiginines and tambjamines

Facile, versatile, and cost-effective synthetic routes for the preparation of a range of new 3-alkyl-, 4-alkyl-, 3,4-dialkyl-, and 3-halo-4-alkyl-2, 2′-bipyrrole-5-carboxaldehydes have been developed. These 2,2′-bipyrrole-5-carboxaldehydes offer interesting potential as building blocks for making bioactive natural and unnatural products, as demonstrated by the synthesis of B-ring functionalized prodiginines (PGs) and tambjamines.

Pyrrolotriazine inhibitors of kinases

The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2, FGFR-1, PDGFR, HER-1, HER-2, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.

Total Synthesis of (+/-)-Bonellin Dimethyl Ester

Bonellin (1) is the green sex-differentiating pigment of Bonellia viridis, a marine animal widely distributed in the Mediterranean Sea.Bonellin dimethylester (rac-2), has been synthesized from the four monocyclic building blocks 6, 7, 8b, 10 and the selectively cleavable malonic ester 9 by an highly convergent synthetic concept. Key Words: Bonellin / Total synthesis / Bonellia virids

LITHIATION OF THE DIMER OF 3-BROMO-6-DIMETHYLAMINO-1-AZAFULVENE. EFFICACIOUS SYNTHESIS OF 4-MONO- AND 4,5-DISUBSTITUTED PYRROLE-2-CARBOXALDEHYDES.

The dimer 1a of 3-bromo-6-dimethylamino-1-azafulvene, is shown to function as a formal equivalent of 4-lithio- or 4,5-dilithiopyrrole-2-carboxaldehyde and consequently it is a progenitor, par excellence, of 4-mono- and 4,5-disubstituted pyrrole-2-carboxaldehydes.

Metabolites of the Marine Sponge Laxosuberites sp.

The marine sponge Laxosuberites sp. contained a mixture of four 5-alkylpyrrole-2-carboxaldehydes 1, (6'Z)-5-(12'-cyano-6'-dodecenyl)pyrrole-2-carboxaldehyde (2), and (6'Z)-5-(23'-cyano-23'-hydroxy-6'-tricosenyl)pyrrole-2-carboxaldehyde (3).The structures of the metabolites were determined by interpretation of spectral data and by chemical degradation.The cyanohydrin 3 is unusually stable to normal isolation and storage procedures.