2403-49-8

Usage

Appearance

Pale yellow crystalline solid

Usage

Synthesis of pharmaceuticals and agricultural chemicals

Chemical structure

Contains a benzene ring with a nitro group and a diethoxymethyl group attached

Classification

Nitroaromatic compound

Utility

Useful as a precursor in the production of various nitrogen-containing organic compounds

Safety precautions

Toxic and can cause irritation to the skin and eyes; handle with caution

Upstream product

• 64-17-5 ethanol 
• 290365-80-9 bis-(α-chloro-3-nitro-benzyl)-ether 
• 99-61-6 3-nitro-benzaldehyde 
• 122-51-0 orthoformic acid triethyl ester 
• 56-23-5 tetrachloromethane 

Downstream Products

• 72538-29-5 N-(3-nitrobenzylidene)-d-10-camphorsulfonamide 
• 73845-02-0 4-methyl-N-(3-nitrobenzylidene)benzenesulfonamide 
• 72581-75-0 (1S,4R)-7,7-Dimethyl-1-[(2S,3S)-3-(3-nitro-phenyl)-oxaziridine-2-sulfonylmethyl]-bicyclo[2.2.1]heptan-2-one 
• 72538-31-9 (1S,4R)-7,7-Dimethyl-1-[(2R,3R)-3-(3-nitro-phenyl)-oxaziridine-2-sulfonylmethyl]-bicyclo[2.2.1]heptan-2-one 
• 67995-01-1 2-(p-toluenesulfonyl)-3-(m-nitrophenyl)oxaziridine 
• 123926-68-1 N-(3-formylphenyl)benzamide 
• 23229-30-3 3-nitrophenyl-1,3-dithiolane 
• 1379662-91-5 4-ethoxy-4-(3-nitrophenyl)-1-butene 

Relevant academic research and scientific papers

Formation of Acetals and Ketals from Carbonyl Compounds: A New and Highly Efficient Method Inspired by Cationic Palladium

The development of a new, highly efficient, and simple method for masking carbonyl groups as acetals and ketals is described. This methodology relies on the nature of the palladium catalyst to direct the acetalization/ketalization reaction. This new protocol is mild and proceed with a very low catalyst loading at ambient temperatures. The method has been extended to a wide variety of different carbonyl compounds with various steric encumbrances to form the corresponding acetals and ketals in excellent yields.

Diverse acetals from stoichiometric amounts of aldehydes and alcohols under very mild conditions: A new twist to PPh3-CCl4 reagent combination

The most frequently utilized method for the preparation of acetals is the reaction of alcohols and aldehydes or ketones, but it suffers from a number of shortcomings: bad thermodynamics, the presence of an acid catalyst and occasionally a complicated reac

A facile and efficient protocol for esterification and acetalization in a PEG1000-D(A)IL/toluene thermoregulated catalyst-media combined systems

A novel efficient and recyclable temperature-dependent biphasic catalyst and reaction media combined system comprised of PEG-1000 linked dicationic acidic ionic liquid and toluene was developed and applied in esterification of aromatic acids and acetalization of aromatic aldehydes with good to excellent yields. This system is characteristic of temperature-dependent reversible biphasic property, simple and facile recyclability, high catalytic activity and extensive substrate and reaction adaptability.

Cobalt(II)-catalyzed chemoselective synthesis of acetals from aldehydes

The acetalization of aldehydes has been studied with methanol, ethanol, and 2-propanol using CoCl2 in high yields under reflux conditions. The reaction is simple, efficient, chemoselective and does not involve any other additive.

A highly efficient and chemoselective method for acetalization of carbonyl compounds catalyzed by TiO2/SO42- solid superacid

Various types of aldehydes and ketones could be converted to their corresponding diethyl acetals with triethylorthoformate in the presence of TiO2/SO42- solid superacid in good to excellent yield under mild reaction conditions.