24036-52-0

Basic information

• Product Name: 6-BROMO-2H-1,4-BENZOXAZIN-3(4H)-ONE
• Synonyms: 6-BROMO-2H-1,4-BENZOXAZIN-3(4H)-ONE;6-BROMO-(2H)-1,4-BENZOXAZINE-3(4H)-ONE;6-BROMO-3-OXO-4H-BENZO[1,4]OXAZINE;6-Bromo-2H-benzo[b][1,4]oxazin-3(4H)-one;6-Bromo-4H-benzo[1,4]oxazin-3-one;6-Bromo-1,4-benzoxazin-3-one;6-bromo-4H-1,4-benzoxazin-3-one;2H-1,4-Benzoxazin-3(4H)-one, 6-bromo-
• CAS NO: 24036-52-0
• Molecular Formula: C₈H₆BrNO₂
• Molecular Weight: 228.04
• Mol File: 24036-52-0.mol
• Article Data: 1

Chemical Properties

• Melting Point: 220-225 °C
• Boiling Point: 376.763 °C at 760 mmHg
• Flash Point: 181.66 °C
• Appearance: /
• Density: 1.676
• Storage Temp.: Room temperature.
• Solubility: DMSO, Methanol
• PKA: 11.89±0.20(Predicted)
• CAS DataBase Reference: 6-BROMO-2H-1,4-BENZOXAZIN-3(4H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-BROMO-2H-1,4-BENZOXAZIN-3(4H)-ONE(24036-52-0)
• EPA Substance Registry System: 6-BROMO-2H-1,4-BENZOXAZIN-3(4H)-ONE(24036-52-0)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36
• WGK Germany: 2
• Hazardous Substances Data: 24036-52-0(Hazardous Substances Data)

Usage

Description

6-Bromo-2H-1,4-benzoxazin-3(4H)-one is an organic compound that serves as a crucial building block in the synthesis of various chemical compounds, particularly pyrimidinyl substituted benzoxazinones and small molecule renin inhibitors. It is characterized by its unique chemical structure and properties, making it a valuable component in the development of pharmaceuticals and other related applications.

Uses

Used in Pharmaceutical Industry:
6-Bromo-2H-1,4-benzoxazin-3(4H)-one is used as a building block for the construction of pyrimidinyl substituted benzoxazinones, which are important in the development of small molecule renin inhibitors. These inhibitors play a significant role in the treatment of hypertension and other cardiovascular diseases by regulating the renin-angiotensin system.
Used in Central Nervous System and Gastrointestinal Tract Applications:
6-Bromo-2H-1,4-benzoxazin-3(4H)-one is also used in the synthesis of substituted benzoxazinones that act as selective 5-HT6 antagonists. These antagonists are utilized in the treatment of central nervous system diseases and gastrointestinal tract disorders by modulating the serotonin receptor, which is involved in various physiological processes and pathways.

Upstream product

• 79-14-1 glycolic Acid 
• 3460-18-2 1,4-dibromo-2-nitrobenzene 

Downstream Products

• 688363-21-5 4-(4-fluoro-benzyl)-6-piperazin-1-yl-4H-benzo[1,4]oxazin-3-one, hydrochloride salt 
• 688363-20-4 4-benzyl-6-piperazin-1-yl-4H-benzo[1,4]oxazin-3-one, hydrochloride salt 
• 105655-01-4 6-bromo-3, 4-dihydro-2H-benzo[β][1, 4]oxazine 
• 24036-49-5 6,7-dibromo-(2H)-1,4-benzoxazin-3(4H)-one 
• 24036-47-3 6-bromo-4-methyl-2H-benzo[b][1,4]oxazin-3(4H)-one 
• 1246765-28-5 (3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)boronic acid 
• 1201844-49-6 N-(2-chloro-5-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide 

Relevant articles and documents

Dihydrobenz thiazine derivative and microorganism control agent

A compound represented by the formula: STR1 wherein R1 and R2 each represent a hydrogen atom, a halogen atom, a nitro group, a lower alkyl group or a trifluoromethyl group; R3 represents a hydrogen atom, a lower alkyl group, a phenyl group or a lower alkoxy-carbonyl group; R4 and R5 each represent a hydrogen atom or a lower alkyl group; R6 represents a halogen atom; and X represents an oxygen atom or a sulfur atom, and a microorganism control agent, comprising the above compound as an active ingredient.