240400-95-7 Usage
Description
6-Bromo-1,4-dichlorophthalazine is a versatile organic chemical compound belonging to the phthalazine class, characterized by the molecular formula C8H4BrCl2N2O2. As a derivative of phthalazine, it incorporates both bromine and chlorine atoms, contributing to its unique chemical properties and potential applications.
Uses
Used in Pharmaceutical and Agrochemical Industries:
6-Bromo-1,4-dichlorophthalazine is utilized as an intermediate in the synthesis of various pharmaceuticals and agrochemicals, playing a crucial role in the development of new drugs and pesticides. Its unique chemical structure allows for the creation of a wide range of compounds with different therapeutic and pesticidal properties.
Used as an Antibacterial and Antifungal Agent:
6-Bromo-1,4-dichlorophthalazine has been studied for its potential use as an antibacterial and antifungal agent. Its chemical composition and properties enable it to target and inhibit the growth of various bacteria and fungi, making it a promising candidate for the development of new antimicrobial agents.
Used as a Precursor in Organic Synthesis:
Due to its versatile chemical structure, 6-Bromo-1,4-dichlorophthalazine serves as a valuable precursor in the synthesis of various organic compounds. It can be further modified and functionalized to produce a range of molecules with different properties and applications, contributing to the advancement of organic chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 240400-95-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,4,0,4,0 and 0 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 240400-95:
(8*2)+(7*4)+(6*0)+(5*4)+(4*0)+(3*0)+(2*9)+(1*5)=87
87 % 10 = 7
So 240400-95-7 is a valid CAS Registry Number.
240400-95-7Relevant articles and documents
COMPOUNDS, COMPOSITIONS AND METHODS
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Paragraph 0220-0221, (2022/02/28)
The present disclosure relates generally to small molecule modulators of NLR Family Pyrin Domain Containing 3 (NLRP3), or a pharmaceutically acceptable salt, isotopically enriched analog, stereoisomer, mixture of stereoisomers, or prodrug thereof, methods of making and intermediates thereof, and methods of using thereof.
N -Chlorinative Ring Contraction of 1,4-Dimethoxyphthalazines via a Bicyclization/Ring-Opening Mechanism
Im, Jeong Kyun,Jeong, Ilju,Yang, Byeongdo,Moon, Hyeon,Choi, Jun-Ho,Chung, Won-Jin
, p. 1760 - 1770 (2020/12/30)
An unprecedented N -chlorinative ring contraction of 1,2-diazines was discovered and investigated with an electrophilic chlorinating reagent, trichloroisocyanuric acid (TCICA). Through optimization and mechanistic analysis, the assisting role of n -Bu 4NCl as an exogenous nucleophile was identified, and the optimized reaction conditions were applied to a range of 1,4-dimethoxyphthalazine derivatives. Also, an improvement of overall efficiency was demonstrated by the use of a labile O -silyl group. A bicyclization/ring-opening mechanism, inspired by the Favorskii rearrangement, was proposed and supported by the DFT calculations. Furthermore, the efforts on scope expansion as well as the evaluation of other electrophilic promoters revealed that the newly developed ring contraction reactivity is a unique characteristic of 1,4-dimethoxyphthalazine scaffold and TCICA.
SOS1 INHIBITORS
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Paragraph 0504, (2021/06/26)
The present invention relates to compounds that inhibit Son of sevenless homolog 1 (SOS1) activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of treating cancer using the compounds and pharmaceutical compositions of the present invention.
