240427-75-2Relevant academic research and scientific papers
Total synthesis and stereochemical revision of relgro and 10′-oxorelgro
Gaddam, Janardhan,Reddy, G. Sudhakar,Marumudi, Kanakaraju,Kunwar, Ajit C.,Yadav, Jhillu S.,Mohapatra, Debendra K.
, p. 5601 - 5614 (2019/06/13)
The first asymmetric total synthesis and stereochemical assignments of 10-membered macrolactones relgro and 10′-oxorelgro are disclosed. To this end, palladium-catalyzed Stille coupling, the Mitsunobu reaction, ring-closing metathesis, EDCI promoted coupling and the Jacobsen hydrolytic kinetic resolution are used as key steps. The total synthesis followed by thorough evaluation of the optical rotation and CD spectral data led to the revision of the absolute configuration at C-6′ for both relgro and 10′-oxorelgro. Moreover, the 1H as well as 13C NMR data are reported for the first time for relgro.
New perspective for natural products synthesis: Concise synthesis of (+)-Sch 642305 by chiral auxiliary multiuse methodology
Fujioka, Hiromichi,Ohba, Yusuke,Nakahara, Kenji,Takatsuji, Mayuko,Murai, Kenichi,Ito, Motoki,Kita, Yasuyuki
, p. 5605 - 5608 (2008/09/17)
The synthesis of (+)-Sch 642305 is an example of chiral auxiliary multiuse methodology, which shows a new perspective for the synthesis of compounds with multiple asymmetric centers. Thus, (+)-Sch 642305 was concisely synthesized from the known compound.
20-Hydroxyeicosatetraenoic Acid (20-HETE): Structural Determinants for Renal Vasoconstriction
Yu, Ming,Alonso-Galicia, Magdalena,Sun, Cheng-Wen,Roman, Richard J.,Ono, Naoya,Hirano, Hitomi,Ishimoto, Tsuyoshi,Reddy, Y. Krishna,Katipally, Kishta Reddy,Reddy, Komandla Malla,Gopal, V. Raj,et al.
, p. 2802 - 2822 (2007/10/03)
The effects of natural and synthetic eicosanoids on the diameter of rat interlobular arteries studied in vitro were compared to that of the potent, endogenous vasoconstrictor 20-HETE. Vasoconstrictor activity was optimum for chain lengths of 20 - 22 carbo
