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115461-39-7

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115461-39-7 Usage

Description

19-HETE is one of the major cytochrome P450 (CYP450) metabolites of arachidonic acid that is released from the kidney in response to angiotensin II. When formed by the CYP2E1 isoform, 19-HETE is composed of 70% and 30% of the (S) and (R) stereoisomers, respectively. Both 19(S)- and 19(R)-HETE are potent vasodilators of renal preglomerular vessels. However, 19(R)-HETE at 1 μM completely blocks 20-HETE-induced vasoconstriction of renal arterioles, whereas 19(S)-HETE remains inactive.

Check Digit Verification of cas no

The CAS Registry Mumber 115461-39-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,5,4,6 and 1 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 115461-39:
(8*1)+(7*1)+(6*5)+(5*4)+(4*6)+(3*1)+(2*3)+(1*9)=107
107 % 10 = 7
So 115461-39-7 is a valid CAS Registry Number.

115461-39-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 19(R)-HETE

1.2 Other means of identification

Product number -
Other names 19R-HYDROXY-5Z,8Z,11Z,14Z-EICOSATETRAENOIC ACID

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:115461-39-7 SDS

115461-39-7Downstream Products

115461-39-7Relevant articles and documents

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Sih,C.J. et al.

, p. 3685 - 3687 (1969)

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Repurposing Resveratrol and Fluconazole to Modulate Human Cytochrome P450-Mediated Arachidonic Acid Metabolism

El-Sherbeni, Ahmed A.,El-Kadi, Ayman O. S.

, p. 1278 - 1288 (2016/04/26)

Cytochrome P450 (P450) enzymes metabolize arachidonic acid (AA) to several biologically active epoxyeicosatrienoic acids (EETs) and hydroxyeicosatetraenoic acids (HETEs). Repurposing clinically-approved drugs could provide safe and readily available means

A practical, stereospecific route to 18-, 19-, and 20-hydroxyeicosa-5(Z), 8(Z),11(Z),14(Z)-tetraenoic acids (18-, 19-, and 20-HETEs)

Gopal, V. Raj,Jagadeesh,Reddy, Y. Krishna,Bandyopadhyay,Capdevila, Jorge H.,Falck

, p. 2563 - 2565 (2007/10/03)

Suzuki-Miyaura cross-coupling of cis-vinylbromide 6, obtained in three steps from diol 4, with functionalized boranes provides a practical, stereospecific route to the title CYP P450 eicosanoids.

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