240427-80-9Relevant academic research and scientific papers
20-HETE RECEPTOR (GPR75) ANTAGONISTS AND METHODS OF USE
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Paragraph 00207, (2017/09/27)
The present invention concerns compounds and their use to treat cardiovascular disease, renal disease, thrombic disease, stroke, metabolic syndrome, cell proliferation, and ischemic cardiovascular disorders. Compounds of the present invention display sign
On the synthesis of pyrinodemin A. Part 1: The location of the olefin
Romeril, Stuart P.,Lee, Victor,Baldwin, Jack E.,Claridge, Timothy D.W.
, p. 1127 - 1140 (2007/10/03)
The elucidation of the structure of the cytotoxic marine sponge alkaloid pyrinodemin A by synthesis is described. Based on the 13C NMR spectra of three double bond positional isomers and the natural product, it is concluded the C14′-C15′ isomer
20-Hydroxyeicosatetraenoic Acid (20-HETE): Structural Determinants for Renal Vasoconstriction
Yu, Ming,Alonso-Galicia, Magdalena,Sun, Cheng-Wen,Roman, Richard J.,Ono, Naoya,Hirano, Hitomi,Ishimoto, Tsuyoshi,Reddy, Y. Krishna,Katipally, Kishta Reddy,Reddy, Komandla Malla,Gopal, V. Raj,et al.
, p. 2802 - 2822 (2007/10/03)
The effects of natural and synthetic eicosanoids on the diameter of rat interlobular arteries studied in vitro were compared to that of the potent, endogenous vasoconstrictor 20-HETE. Vasoconstrictor activity was optimum for chain lengths of 20 - 22 carbo
Studies toward the total synthesis of the cytotoxic sponge alkaloid pyrinodemin A.
Baldwin,Romeril,Lee,Claridge
, p. 1145 - 1148 (2007/10/03)
[structure: see text]. The syntheses of the proposed structure of pyrinodemin A (1) and its cis double bond positional isomer (C15'-C16') in racemic form are described. The key reaction involved an intramolecular nitrone/double bond cycloaddition. Our res
