24043-42-3

Upstream product

• 29182-87-4 2-bromo-N-(4-methoxyphenyl)acetamide 
• 685-87-0 Diethyl 2-bromomalonate 
• 24043-41-2 N-(p-Methoxy-phenyl)-N-chloracetylamino-malonsaeure-diethylester 
• 106817-55-4 diethyl 2-(2-bromo-N-(4-methoxyphenyl)acetamido)malonate 
• 106817-58-7 Diethyl N-bromoacetyl-N-(4-methoxyphenyl)-aminobromomalonate 
• 24043-40-1 diethyl 2-[(4-methoxyphenyl)amino]malonate 

Downstream Products

• 221910-46-9 1-(4'-methoxyphenyl)-3-phenylthio-4,4-diethoxycarbonyl-azetidin-2-one 
• 188881-49-4 1-(4-Methoxy-phenyl)-7,7-dimethyl-6,8-dioxa-1-aza-spiro[3.5]nonan-2-one 
• 188881-55-2 [2,2-Bis-hydroxymethyl-1-(4-methoxy-phenyl)-4-oxo-azetidin-3-yl]-carbamic acid benzyl ester 
• 188881-51-8 [1-(4-Methoxy-phenyl)-7,7-dimethyl-2-oxo-6,8-dioxa-1-aza-spiro[3.5]non-3-yl]-carbamic acid benzyl ester 

Relevant academic research and scientific papers

Reactivity of electrogenerated N-heterocyclic carbenes in room-temperature ionic liquids. Cyclization to 2-azetidinone ring via C-3/C-4 bond formation

The intrinsic chemistry of imidazolium-based room-temperature ionic liquids, related to the acidity of the C-2 imidazolium cation, can be modified via cathodic cleavage of the C-2/hydrogen bond. N-Heterocyclic carbenes, electrogenerated by electrolysis of

Electrochemical Studies on Haloamides. Part 4. Reactivity of Haloacetamides and Haloacetohydroxamates Toward Electrogenerated Diethyl Malonate Anion

The reactivity of haloacetamides and acetohydroxamates 1 and 2 toward electrogenerated diethyl malonate anion has been investigated.The course of the reaction primarily depends on the acidity of the amide NH group, which is mainly determined by the nature of the substituent, R, at the nitrogen atom.If this substituent is the same, the nature of the halogen atom also plays an important role.If the malonate anion can act as a base, products arising from follow-up reactions of the conjugated base of the substrate are formed and their structure is dependent on R.In particular, β-lactams arising from a formal insertion of a malonate residue into the amide skeleton are obtained from haloacetanilides.When the substrate cannot be deprotonated, the diethyl malonate anion behaves as a nucleophile provided that the leaving group is bromide.Chloro derivatives are rather stable toward malonate anion.

Electrochemical Behaviour of ο-Bromoalkanamides. Electrosynthesis of β-, γ-, and δ-Lactams

The electrochemical behaviour of bromoamides 1-3 in dimethylformamide solution at a Hg cathode has been investigated by means of cyclic voltammetry at various scan rates and controlled-potential electrolysis.All compounds undergo a facile, high yielding r