24043-40-1

Upstream product

• 104-94-9 4-methoxy-aniline 
• 685-87-0 Diethyl 2-bromomalonate 

Downstream Products

• 83304-69-2 3-Hydroxy-1-(4-methoxy-phenyl)-3-methyl-5-oxo-pyrrolidine-2,2-dicarboxylic acid diethyl ester 
• 126736-93-4 2-[(4-Bromo-butyryl)-(4-methoxy-phenyl)-amino]-malonic acid diethyl ester 
• 126736-88-7 2-[(3-Bromo-propionyl)-(4-methoxy-phenyl)-amino]-malonic acid diethyl ester 
• 87542-26-5 (2S,3R)-1-(4-Methoxy-phenyl)-3-(2-methyl-[1,3]dioxolan-2-yl)-4-oxo-azetidine-2-carboxylic acid ethyl ester 
• 87542-26-5 (2R,3R)-1-(4-Methoxy-phenyl)-3-(2-methyl-[1,3]dioxolan-2-yl)-4-oxo-azetidine-2-carboxylic acid ethyl ester 
• 87542-25-4 1-(4-Methoxy-phenyl)-3-(2-methyl-[1,3]dioxolan-2-yl)-4-oxo-azetidine-2,2-dicarboxylic acid diethyl ester 
• 83304-70-5 3-Acetyl-1-(4-methoxy-phenyl)-4-oxo-azetidine-2,2-dicarboxylic acid diethyl ester 
• 106817-58-7 Diethyl N-bromoacetyl-N-(4-methoxyphenyl)-aminobromomalonate 
• 106817-59-8 3-Chloro-1-(4-methoxy-phenyl)-4-oxo-azetidine-2,2-dicarboxylic acid diethyl ester 
• 24043-42-3 diethyl 1-(4-methoxyphenyl)-4-oxoazetidine-2,2-dicarboxylate 
• 126737-05-1 1-(4-Methoxy-phenyl)-6-oxo-piperidine-2,2-dicarboxylic acid diethyl ester 
• 126737-06-2 2-[Butyryl-(4-methoxy-phenyl)-amino]-malonic acid diethyl ester 
• 126737-04-0 2-[(4-Methoxy-phenyl)-propionyl-amino]-malonic acid diethyl ester 

Relevant academic research and scientific papers

A convenient synthesis of 3-phenylthio-azetidin-2-ones

3-Phenylthio-4,4-diethoxycarbonyl-azetidin-2-ones 8 have been conveniently synthesised by reacting 2-chlorophenylthioacetyl chloride 5 with aryl substituted aminomalonates 7 under mild basic conditions. Alternatively, C-3 alkylation of azetidin-2-one usin

SIMPLE AND CONDENSED β-LACTAMS-I. THE APPLICATION OF DIKETENE IN β-LACTAM SYNTHESIS. THE SYNTHESIS AND FUNCTIONAL GROUP MANIPULATIONS OF DIETHYL 3-ACETYL-4-OXOAZETIDINE-2,2-DICARBOXYLATES

Acetylation of the N-substituted diethyl aminomalonates 3a-3d with diketene furnished the ring tautomers 6a-6d of the expected acetoacetyl derivatives 5.By treatment with iodine and sodium ethoxide compounds 6a-6d are smoothly converted into the β-lactam