24048-14-4Relevant articles and documents
Total Synthesis of (±)-Liphagal via Organic-Redox-Driven Palladium-Catalyzed Hydroxybenzofuran Formation
Tao, Eriko,Inoue, Masaki,Jeong, Taejoo,Kim, In Su,Yoshimitsu, Takehiko
, p. 9064 - 9070 (2020/07/14)
A synthetic route to liphagal, a natural PI3Kα inhibitor isolated from Aka coralliphaga, was established. The present route features an organic redox process where an alkynylquinone undergoes reductive cyclization in the presence of a hydroquinone derivative such as hydroxyquinol (1,2,4-benzenetriol) and catalytic PdCl2 to provide a substituted benzofuran suitable for accessing the natural product. The benzofuran formation takes place via the redox transformation between the alkynylquinone and the electron-rich hydroquinones followed by the concomitant Pd(II)-catalyzed oxycyclization of the resultant alkynylhydroquinone.
Zirconium-catalyzed asymmetric carboalumination of alkenes: ZACA-lipase-catalyzed acetylation synergy
Huang, Zhihong,Tan, Ze,Novak, Tibor,Zhu, Gangguo,Negishi, Ei-Ichi
, p. 539 - 545 (2008/02/08)
ZACA-lipase-catalyzed acetylation tandem reactions provide highly efficient and selective routes to either (R)- or (S)-2-methyl-1-alkanols, making, for the first time, the ZACA-based asymmetric synthesis of 2-methyl-1-alkanols widely applicable and satisfactory.
Synthesis and evaluation of aziridine analogues of presqualene diphosphate as squalene synthase inhibitors
Koohang, Ali,Coates, Robert M.,Owen, David,Poulter, C. Dale
, p. 6 - 7 (2007/10/03)
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