24050-09-7

Upstream product

• 52-90-4 L-Cysteine 
• 123-38-6 propionaldehyde 
• 60-23-1 Cysteamine 

Downstream Products

• 1365997-38-1 C₂₀H₁₇FN₂O₂S₂ 
• 1365998-75-9 methyl 1-(4-(6-((S)-2-ethylthiazolidine-3-carbonyl)benzo[d]thiazol-2-yl)-3-fluorobenzyl)azetidine-3-carboxylate 
• 1365997-55-2 methyl 1-(4-(6-((R)-2-ethylthiazolidine-3-carbonyl)benzo[d]thiazol-2-yl)-3-fluorobenzyl)azetidine-3-carboxylate 
• 1356679-58-7 methyl 1-(4-(6-(2-ethylthiazolidine-3-carbonyl)benzo[d]thiazol-2-yl)-3-fluorobenzyl)azetidine-3-carboxylate 

Relevant academic research and scientific papers

Mechanistic Studies on Thiazolidine Formation in Aldehyde/Cysteamine Model Systems

A mechanism was proposed to elucidate the formation of a thiazolidine in aldehyde/cysteamine model systems. Buffer dramatically promotes thiazolidine formation from formaldehyde and cysteamine. Phosphate tends to stabilize the primary carbocation formed, and this may lead to completion of the cyclization by attack of the amino nitrogen on the activated carbon. Protic solvent, by removing the water molecule, further enhances thiazolidine formation. Redox reaction catalyzed by phosphate ions results in the conversion of thiazolidine to the corresponding thiazoline through hydride transfer.

Volatile Products Formed from L-Cysteine and Propanal Thermally Treated in Triglyceride-Water Systems

Volatile compounds formed from model systems of equimolar amounts of L-cysteine and propanal reacted at 110 deg C for 3 h in triglyceride, deionized and distilled water, or their mixtures were investigated.The volatiles were isolated by ether extraction of vacuum steam-distillated of reaction mixtures and analyzed by gas chromatography and coupled gas chromatography-mass spectrometry.Qualitative and quantitative differences in volatiles formed in the systems were observed.The amounts of total volatiles were highly varied according to the composition of the reaction medium. 2-Ethylthiazolidine was the most predominant in the triglyceride sstem. 2-Methyl-2-pentenal was a sevcondary dominating product in the triglyceride system and the most predominant in the triglyceride-water and water systems.The amounts of other volatile compounds including a novel compound, 2-ethylthiazolidinthiazolidine (I), were also changed according to the systems.The highest production of I was observed in the triglyceride-water (75:25) system.