24052-18-4Relevant academic research and scientific papers
Functionalized pyrazoles as agents in C-C cross-coupling reactions
Pejic, Marijana,Popp, Sebastian,Bolte, Michael,Wagner, Matthias,Lerner, Hans-Wolfram
, p. 83 - 97 (2014/06/09)
The 1-tetrahydropyranyl-(THP-)protected pyrazoles 4-R-pz(THP) (R=pinacolatoboryl=Bpin (3a(THP)), Me3Si (4a(THP)), Me3Sn (5a(THP)), and 4-R-3,5-Ph2pz (R=Bpin (3b(THP)), Me3Si (4b(THP)), Me3Sn (5b(THP))
One-pot synthesis of pyrazoles through a four-step cascade sequence
Hao, Lu,Hong, Jun-Jie,Zhu, Jun,Zhan, Zhuang-Ping
supporting information, p. 5715 - 5720 (2013/06/04)
A one-pot synthesis of 3,4,5- and 1,3,5-pyrazoles from tertiary propargylic alcohols and para-tolylsulfonohydrazide has been accomplished. The pyrazoles are formed through a four-step cascade sequence, including FeCl 3-catalyzed propargylic substitution, aza-Meyer-Schuster rearrangement, base-mediated 6πelectrocyclization, and thermal [1,5] sigmatropic shift. In this reaction, the 3,4,5- and 1,3,5-pyrazoles are produced selectively according to different substituents in the starting alcohols. A one-pot recipe: The synthesis of 3,4,5- and 1,3,5-pyrazoles from tertiary propargylic alcohols and para-tolylsulfonohydrazide has been accomplished. The pyrazoles are formed through a four-step cascade sequence (see figure), and are produced selectively according to different substituents in the starting alcohols.
