240800-48-0 Usage
General Description
2,3,5-Trifluorobenzoyl chloride is a chemical compound with the formula C7H2F3ClO. It is a colorless to pale yellow liquid that is used as a versatile building block in organic synthesis. 2,3,5-TRIFLUOROBENZOYL CHLORIDE is primarily used as a reagent for the synthesis of various pharmaceuticals, agrochemicals, and other specialty chemicals. It is also used in the production of polymers, dyes, and flavorings. 2,3,5-Trifluorobenzoyl chloride is a highly reactive and corrosive compound, and proper safety precautions should be taken when handling it.
Check Digit Verification of cas no
The CAS Registry Mumber 240800-48-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,4,0,8,0 and 0 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 240800-48:
(8*2)+(7*4)+(6*0)+(5*8)+(4*0)+(3*0)+(2*4)+(1*8)=100
100 % 10 = 0
So 240800-48-0 is a valid CAS Registry Number.
InChI:InChI=1/C7H2ClF3O/c8-7(12)4-1-3(9)2-5(10)6(4)11/h1-2H
240800-48-0Relevant articles and documents
Novel quinazoline derivatives bearing various 6-benzamide moieties as highly selective and potent EGFR inhibitors
Hou, Weijie,Ren, Yan,Zhang, Zhenhua,Sun, Huan,Ma, Yongfen,Yan, Bo
, p. 1740 - 1750 (2018/03/12)
A series of novel quinazoline derivatives bearing various C-6 benzamide substituents were synthesized and evaluated as EGFR inhibitors, and most showed significant inhibitory potency against EGFR kinase. In particular, compound 6g possessed potent inhibitory activity against EGFR wild-type (IC50 = 5 nM), and strong antiproliferative activity against HCC827 and Ba/F3 (L858R) cell lines. Kinase profiling against a panel of 365 kinases showed that 6g was highly selective for EGFR. Furthermore, 6g showed desirable properties in assays of liver microsome metabolic stability and cytochromes P450 inhibition and preliminary pharmacokinetic study. The overall attractive profile of 6g made it an interesting compound for further development.
