240802-91-9

Upstream product

• 693-03-8 n-butyl magnesium bromide 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 109-72-8 n-butyllithium 
• 58980-10-2 1',2',3',4'-tetrahydro-spiro(1.3-dioxolane-2,1'-naphthalene) 

Downstream Products

• 92013-24-6 1-n-butyl-3,4-dihydronaphthalene 
• 38857-76-0 1-Butyl-tetralin 

Relevant academic research and scientific papers

Deprotection of 1,3-oxathiolanes to ketones promoted by base

A variety of 1,3-oxathiolanes can be easily converted to the corresponding ketones in good yields with LTMP in THF. This deprotection methodology shows satisfactory chemoselectivity when other protecting groups, such as dimethylketal, 1,3-dioxolane, 1,3-dithiane, and other acid-sensitive groups, are present within the same substrates.

A base-promoted deprotection of 1,3-dioxolanes to ketones

An effective deprotection methodology of dioxolanes was developed, affording moderate to excellent yield via a LTMP-promoted reaction in THF, which displays admirable chemoselectivity in the presence of dimethylketal, 1,3-dioxane, 1,3-dithiane, or other acid-sensitive protective groups.