92013-24-6Relevant academic research and scientific papers
Iron-catalyzed alkenylation of Grignard reagents by enol phosphates
Cahiez, Gerard,Gager, Olivier,Habiak, Vanessa
experimental part, p. 2636 - 2644 (2009/04/07)
Stereoselective preparation of trisubstituted olefins can be easily performed from an Z/E-mixture of enol phosphates by reacting only the E-isomer with a Grignard reagent in the presence of Fe(acac)3. This procedure combines a kinetic differentiation and a stereoselective reaction. The coupling is very chemoselective in the presence of an alkyl chloride, an ester, a ketone or a nitrile. Georg Thieme Verlag Stuttgart.
Silica Chloride (SiO2-Cl) and Trimethylsilyl Chloride (TMSCl) Promote Facile and Efficient Dehydration of Tertiary Alcohols
Firouzabadi, Habib,Iranpoor, Naser,Hazarkhani, Hassan,Karimi, Babak
, p. 3653 - 3660 (2007/10/03)
Silica chloride (SiO2-Cl), as a heterogeneous reagent, has been used for the efficient dehydration of tertiary alcohols under mild reaction conditions. For comparison, we have also used trimethylsilyl chloride (TMSCl) as a homogeneous reagent for this purpose. We have found that silica chloride is a more efficient reagnet than trimethylsilyl chloride for this purpose. Handling of SiO2-Cl is much safer and easier than TMSCl, especially for large-scale operation. The selectivity of the method is also demonstrated by several competitive reactions. Ether formation, rearranged products, and polymerization have not been observed in the reactions.
Palladium-catalyzed cross coupling of Grignard reagents with in situ-derived enol phosphates
Miller, Joseph A.
, p. 7111 - 7114 (2007/10/03)
A useful, one-pot protocol has been developed for the conversion of enolizable ketones to alkylated or arylated olefins by Pd-catalyzed cross coupling of in situ-generated enol phosphate intermediates with Grignard reagents.
Synthesis of Biological Markers in Fossil Fuels. 2. Synthesis and 13C NMR Studies of Substituted Indans and Tetralins
Adamczyk, Maciej,Watt, David S.,Netzel, Daniel A.
, p. 4226 - 4237 (2007/10/02)
Unambiguous syntheses of all possible methyl, ethyl, n-propyl, and n-butyl derivatives of indan and tetralin were developed using the Kumada coupling procedure involving the reaction of aryl or vinyl halides with Grignard reagents in the presence of nickel(II) chloride.An analysis of the 13C NMR spectra of these compounds was also completed.
