2409-36-1Relevant articles and documents
Metal-Free Hydroxymethylation of Indole Derivatives with Formic Acid as an Alternative Way to Indirect Utilization of CO2
Huang, Wen-Bin,Yang, Meng,He, Liang-Nian
, p. 3775 - 3779 (2022/02/10)
The selective N-alkylation of indole substrates remains an ongoing research challenge for the relative attenuated nucleophilicity toward nitrogen. Herein, we developed the hydroxymethylation of indole derivatives to afford N-alkylated indole products with
Synthesis of some N-substituted carbazoles and their larvicidal studies
Das,Begum,Choudhury,Banerji
, p. 158 - 160 (2007/10/03)
Some N-substituted carbazoles have been synthesized and a comparative larvicidal study has also been done on the larvae of Culex quinquefasciatus.
Model Systems for Cytochrome P450-dependent Mono-oxygenases. Part 5. Amine Oxidation. Part 17. Oxidative N-Dealkylation of Tertiary Amines by Metalloporphyrin-catalysed Model Systems for Cytochrome P450 Monooxygenases
Smith, John R. Lindsay,Mortimer, David N.
, p. 1743 - 1750 (2007/10/02)
NN-Dimethylbenzylamine has been oxidatively demethylated to N-methylbenzylamine and debenzylated to benzaldehyde by iodosylbenzene and by t-butyl hydroperoxide catalysed by tetraphenylporphinato-iron(III) or -manganese(III) chloride.The influence of substituents on the aromatic ring and of deuteration of the benzylic hydrogens on the relative reactivity of the substrates and on the product distribution has been stidied.The results suggest that the initial step in the metalloporphyrin-catalysed iodosylbenzene oxidations is an electron-transfer from the amine to a high valent oxometal species, whereas, with t-butyl hydroperoxide the mechanism is one of hydrogen abstraction from the amine by the t-butoxyl radical.The mechanisms of the subsequent steps are discussed.
