24099-80-7

Upstream product

• 29271-65-6 methyl 13-α-hydroxyisopropyl-12-methoxypodocarpa-8,11,13-trien-19-oate 
• 128344-80-9 (1S,4aS,10aR)-dimethyl 6-methoxy-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1,7-dicarboxylate 
• 75-16-1 methylmagnesium bromide 
• 1231-74-9 methyl O-methylpodocarpate 
• 29271-64-5 methyl 13-acetyl-12-methoxypodocarpa-8,11,13-trien-19-oate 

Downstream Products

• 30320-64-0 19-hydroxyferruginol 
• 81752-79-6 2-<2-<3-hydroxy-4-(2-hydroxy-1-methylethyl)-benzoquinone-2,5>yl-2,6,6-trimethylcyclohexyl>ethanoic acid 
• 81752-80-9 [(1S,2S)-4'-((R)-2-Hydroxy-1-methyl-ethyl)-5'-methoxy-1,3,3-trimethyl-3',6'-dioxo-bicyclohexyl-1',4'-dien-2-yl]-acetic acid 
• 81752-78-5 [(1S,2S)-4'-((R)-2-Acetoxy-1-methyl-ethyl)-5'-bromo-1,3,3-trimethyl-3',6'-dioxo-bicyclohexyl-1',4'-dien-2-yl]-acetic acid 
• 81752-76-3 2-<4-<(S)-2-acetoxy-1-methylethyl>-2,5-dioxo-1(6),3-cyclohexadienyl>-2,6,6-trimethylcyclohexaneacetic acid 
• 81768-72-1 2-<2-<4-(2-acetoxy-1(R)-methylethyl)-benzoquinone-2,5>yl-2,6,6-trimethylcyclohexyl>ethanoic acid 
• 81752-77-4 [(1S,2S)-4'-((S)-2-Acetoxy-1-methyl-ethyl)-4',5'-dibromo-1,3,3-trimethyl-3',6'-dioxo-bicyclohexyl-1'-en-2-yl]-acetic acid 

Relevant academic research and scientific papers

PHENOLIC DITERPENOIDS OF PODOCARPUS FERRUGINEUS AND OTHER PODOCARPS

19-Hydroxyferruginol and 19-acetoxyferruginol, two new naturally occuring phenolic diterpenoids, have been isolated from the heartwood of Podocarpus ferrugineus.Totarol and its derivatives have been obtained from Podocarpus affinis, P. falcatus, P. koordersii, Dacrycarpus vieillardii and Decussocarpus comptonii and podocarpic acid from Falcatifolium taxoides. - Keywords: Podocarpus ferrugineus; Podocarpus spp.; Dacrycarpus vieillardii; Decussocarpus comptonii; Prumnopitys ferrugineus; Falcatifolium taxoides; Podocarpaceae; phenolic diterpenoids; 19-hydroxyferruginol; 19-acetoxyferruginol; chemotaxonomy.

Synthesis and antiproliferative activity of podocarpane and totarane derivatives

The synthesis of podocarpanes, including 12,19-dihydroxy-13-acetyl-8,11,13-podocarpatriene (23), isolated from Gaultheria yunnanensis and not previously synthesized, and totarane-type terpenoids, starting from the natural labdane trans-communic acid (15), is described. Their antiproliferative activities against MCF-7, T-84 and A-549 human tumoural cell lines are studied. An antiproliferative effect was induced by compounds 23, 27 and 28, with IC50 A-549 cells (IC50 0.6 μM) through a mechanism that involves the induction of apoptosis mediated by an increased Bax/Bcl-2 ratio. The results of the present study indicate that compound 28, at least, might be useful as an antitumoral agent. Further studies are required to elucidate the cellular and molecular elements involved in its effect, and the activity/toxicity in preclinical models.