241-55-4

Usage

Uses

Used in Cancer Prevention and Treatment:
Indolo(3,2-b)carbazole is used as a chemopreventive agent for its potential to reduce the risk of developing cancer. It modulates the metabolism of estrogen and other hormones, which are often implicated in the development of hormone-dependent cancers. Additionally, I3C induces cancer cell death and inhibits tumor growth, making it a valuable compound in the fight against cancer.
Used in Antioxidant and Anti-inflammatory Applications:
Indolo(3,2-b)carbazole is utilized as an antioxidant to neutralize harmful free radicals and protect cells from oxidative damage. Its anti-inflammatory properties also contribute to its protective effects against various diseases, including chronic inflammatory conditions and autoimmune disorders.
Used in Pharmaceutical Industry:
I3C is employed as a pharmaceutical compound for the development of novel therapeutic agents targeting cancer and other chronic diseases. Its multifaceted mechanisms of action, including hormone regulation, cancer cell death induction, and antioxidant and anti-inflammatory properties, make it a versatile candidate for drug development.
Used in Functional Foods and Nutraceuticals:
Indolo(3,2-b)carbazole is incorporated into functional foods and nutraceutical products to provide health benefits beyond basic nutrition. Its presence in cruciferous vegetables and its potential to promote human health and prevent chronic diseases make it an attractive ingredient for these products.

InChI:InChI=1/C18H10N2/c1-3-7-15-11(5-1)13-9-18-14(10-17(13)19-15)12-6-2-4-8-16(12)20-18/h1-10H

Upstream product

• 352712-51-7 Malassezin 
• 114648-66-7 (1H-indol-3-yl)-(1H-indol-2-yl)-methane 
• 120-72-9 indole 
• 75-75-2 methanesulfonic acid 
• 6336-32-9 5H,11H-indolo[3,2-b]carbazole 
• 87-51-4 indole-3-acetic acid 
• 7664-93-9 sulfuric acid 
• 7782-77-6 cis-nitrous acid 
• 7722-84-1 dihydrogen peroxide 

Relevant academic research and scientific papers

Revisiting Indolo[3,2-b]carbazole: Synthesis, Structures, Properties, and Applications

Indolo[3,2-b]carbazole presents a π-skeleton with a remarkable electronic structure and interesting potential applications. It is, however, also associated with ambiguity and controversy. Herein, new derivatives of indolo[3,2-b]carbazole are reported and they have enabled a comprehensive study on the electronic structure of indolo[3,2-b]carbazole and the development of a new n-type organic semiconductor. Experimental and computational studies show that indolo[3,2-b]carbazole has a largely localized p-benzoquinonediimine moiety and significant antiaromaticity. When substituted with (4-silylethynyl)phenyl groups, the indolo[3,2-b]carbazole exhibits one-dimensional π–π stacking and functions as an n-type organic semiconductor in solution-processed field effect transistors.

PHOTOPROTECTIVE COMPOSITIONS CONTAINING MALASSEZIA-DERIVED COMPOUNDS AND/OR CHEMICAL ANALOGS THEREOF

The present invention relates to compounds, compositions, and methods for modulating skin pigmentation and treating or preventing UV-induced skin damage, erythema, aging of the skin, sunburn, and hyperpigmentation in a subject. The compounds, compositions, and methods of the present invention generally involve Malassezia-derived compounds, including malassezin and indirubin, and/or chemical analogs thereof. Other applications of the compounds and compositions disclosed herein include, but are not limited to, improving hyperpigmentation caused by a hyperpigmentation disorder, inducing melanocyte apoptosis, and modulating arylhydrocarbon receptor (AhR) activity, melanogenesis, melanin production, melanosome biogenesis, melanosome transfer, melanocyte activity, and melanin concentration.

Indolo[3,2-b]carbazole structure unit-containing piezochromic material and application thereof

The invention discloses an indolo[3,2-b]carbazole structure unit-containing piezochromic material. The piezochromic material has a structural formula shown in the description; and in the description, R represents a hydrogen atom, a methyl group, an ethyl group or an isopropyl group, n represents 1, 2 or 3, and Ar represents one of groups also shown in the description. The invention also discloses an application of the indolo[3,2-b]carbazole structure unit-containing piezochromic material in electroluminescent devices. The piezochromic material has the advantages of no toxicity, simple preparation technology, low cost and excellent piezochromic performance.